A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening

Analysis of agonist-driven phosphorylation of G protein-coupled receptors (GPCRs) can provide valuable insights into the receptor activation state and ligand pharmacology. However, to date, assessment of GPCR phosphorylation using high-throughput applications has been challenging. We have developed...

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Detalles Bibliográficos
Autores principales: Kaufmann, Johanna, Blum, Nina Kathleen, Nagel, Falko, Schuler, Anna, Drube, Julia, Degenhart, Carsten, Engel, Julian, Eickhoff, Jan Eicke, Dasgupta, Pooja, Fritzwanker, Sebastian, Guastadisegni, Maria, Schulte, Clemens, Miess-Tanneberg, Elke, Maric, Hans Michael, Spetea, Mariana, Kliewer, Andrea, Baumann, Matthias, Klebl, Bert, Reinscheid, Rainer K., Hoffmann, Carsten, Schulz, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646841/
https://www.ncbi.nlm.nih.gov/pubmed/36352263
http://dx.doi.org/10.1038/s42003-022-04135-9

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