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Pilot study in human healthy volunteers on the use of magnetohydrodynamics in needle-free continuous glucose monitoring
The benefits of continuous glucose monitoring (CGM) in diabetes management are extensively documented. Yet, the broader adoption of CGM systems is limited by their cost and invasiveness. Current CGM devices, requiring implantation or the use of hypodermic needles, fail to offer a convenient solution...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646842/ https://www.ncbi.nlm.nih.gov/pubmed/36351930 http://dx.doi.org/10.1038/s41598-022-21424-9 |
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author | Hakala, Tuuli A. Zschaechner, Laura K. Vänskä, Risto T. Nurminen, Teemu A. Wardale, Melissa Morina, Jonathan Boeva, Zhanna A. Saukkonen, Reeta Alakoskela, Juha-Matti Pettersson-Fernholm, Kim Hæggström, Edward Bobacka, Johan García Pérez, Alejandro |
author_facet | Hakala, Tuuli A. Zschaechner, Laura K. Vänskä, Risto T. Nurminen, Teemu A. Wardale, Melissa Morina, Jonathan Boeva, Zhanna A. Saukkonen, Reeta Alakoskela, Juha-Matti Pettersson-Fernholm, Kim Hæggström, Edward Bobacka, Johan García Pérez, Alejandro |
author_sort | Hakala, Tuuli A. |
collection | PubMed |
description | The benefits of continuous glucose monitoring (CGM) in diabetes management are extensively documented. Yet, the broader adoption of CGM systems is limited by their cost and invasiveness. Current CGM devices, requiring implantation or the use of hypodermic needles, fail to offer a convenient solution. We have demonstrated that magnetohydrodynamics (MHD) is effective at extracting dermal interstitial fluid (ISF) containing glucose, without the use of needles. Here we present the first study of ISF sampling with MHD for glucose monitoring in humans. We conducted 10 glucose tolerance tests on 5 healthy volunteers and obtained a significant correlation between the concentration of glucose in ISF samples extracted with MHD and capillary blood glucose samples. Upon calibration and time lag removal, the data indicate a Mean Absolute Relative Difference (MARD) of 12.9% and Precision Absolute Relative Difference of 13.1%. In view of these results, we discuss the potential value and limitations of MHD in needle-free glucose monitoring. |
format | Online Article Text |
id | pubmed-9646842 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-96468422022-11-15 Pilot study in human healthy volunteers on the use of magnetohydrodynamics in needle-free continuous glucose monitoring Hakala, Tuuli A. Zschaechner, Laura K. Vänskä, Risto T. Nurminen, Teemu A. Wardale, Melissa Morina, Jonathan Boeva, Zhanna A. Saukkonen, Reeta Alakoskela, Juha-Matti Pettersson-Fernholm, Kim Hæggström, Edward Bobacka, Johan García Pérez, Alejandro Sci Rep Article The benefits of continuous glucose monitoring (CGM) in diabetes management are extensively documented. Yet, the broader adoption of CGM systems is limited by their cost and invasiveness. Current CGM devices, requiring implantation or the use of hypodermic needles, fail to offer a convenient solution. We have demonstrated that magnetohydrodynamics (MHD) is effective at extracting dermal interstitial fluid (ISF) containing glucose, without the use of needles. Here we present the first study of ISF sampling with MHD for glucose monitoring in humans. We conducted 10 glucose tolerance tests on 5 healthy volunteers and obtained a significant correlation between the concentration of glucose in ISF samples extracted with MHD and capillary blood glucose samples. Upon calibration and time lag removal, the data indicate a Mean Absolute Relative Difference (MARD) of 12.9% and Precision Absolute Relative Difference of 13.1%. In view of these results, we discuss the potential value and limitations of MHD in needle-free glucose monitoring. Nature Publishing Group UK 2022-11-09 /pmc/articles/PMC9646842/ /pubmed/36351930 http://dx.doi.org/10.1038/s41598-022-21424-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Hakala, Tuuli A. Zschaechner, Laura K. Vänskä, Risto T. Nurminen, Teemu A. Wardale, Melissa Morina, Jonathan Boeva, Zhanna A. Saukkonen, Reeta Alakoskela, Juha-Matti Pettersson-Fernholm, Kim Hæggström, Edward Bobacka, Johan García Pérez, Alejandro Pilot study in human healthy volunteers on the use of magnetohydrodynamics in needle-free continuous glucose monitoring |
title | Pilot study in human healthy volunteers on the use of magnetohydrodynamics in needle-free continuous glucose monitoring |
title_full | Pilot study in human healthy volunteers on the use of magnetohydrodynamics in needle-free continuous glucose monitoring |
title_fullStr | Pilot study in human healthy volunteers on the use of magnetohydrodynamics in needle-free continuous glucose monitoring |
title_full_unstemmed | Pilot study in human healthy volunteers on the use of magnetohydrodynamics in needle-free continuous glucose monitoring |
title_short | Pilot study in human healthy volunteers on the use of magnetohydrodynamics in needle-free continuous glucose monitoring |
title_sort | pilot study in human healthy volunteers on the use of magnetohydrodynamics in needle-free continuous glucose monitoring |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646842/ https://www.ncbi.nlm.nih.gov/pubmed/36351930 http://dx.doi.org/10.1038/s41598-022-21424-9 |
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