Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2

BACKGROUND: Targeting helper T cells, especially Th17 cells, has become a plausible therapy for many autoimmune diseases. METHODS: Using an in vitro culture system, we screened an epigenetics compound library for inhibitors of IFN-γ and IL-17 expression in murine Th1 and Th17 cultures. FINDINGS: Thi...

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Detalles Bibliográficos
Autores principales: Hu, Xiao, Zou, Yanli, Copland, David A., Schewitz-Bowers, Lauren P., Li, Yan, Lait, Philippa J.P., Stimpson, Madeleine, Zhang, Zhihui, Guo, Shixin, Liang, Juanran, Chen, Tingting, Li, Jing Jing, Yuan, Sujing, Li, Shuo, Zhou, Penghui, Liu, Yizhi, Dick, Andrew D., Wen, Xiaofeng, Lee, Richard W.J., Wei, Lai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646865/
https://www.ncbi.nlm.nih.gov/pubmed/36335665
http://dx.doi.org/10.1016/j.ebiom.2022.104333

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