Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide)

In mammals, nicotinamide (NAM) is the primary NAD precursor available in circulation, a signaling molecule, and a precursor for methyl-nicotinamide (M-NAM) synthesis. However, our knowledge about how the body regulates tissue NAM levels is still limited. Here we demonstrate that dietary vitamin B(3)...

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Detalles Bibliográficos
Autores principales: Zeidler, Julianna D., Chini, Claudia C.S., Kanamori, Karina S., Kashyap, Sonu, Espindola-Netto, Jair M., Thompson, Katie, Warner, Gina, Cabral, Fernanda S., Peclat, Thais R., Gomez, Lilian Sales, Lopez, Sierra A., Wandersee, Miles K., Schoon, Renee A., Reid, Kimberly, Menzies, Keir, Beckedorff, Felipe, Reid, Joel M., Brachs, Sebastian, Meyer, Ralph G., Meyer-Ficca, Mirella L., Chini, Eduardo Nunes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646960/
https://www.ncbi.nlm.nih.gov/pubmed/36388973
http://dx.doi.org/10.1016/j.isci.2022.105431

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