Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway

The nucleolar surveillance pathway monitors nucleolar integrity and responds to nucleolar stress by mediating binding of ribosomal proteins to MDM2, resulting in p53 accumulation. Inappropriate pathway activation is implicated in the pathogenesis of ribosomopathies, while drugs selectively activatin...

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Detalles Bibliográficos
Autores principales: Hannan, Katherine M., Soo, Priscilla, Wong, Mei S., Lee, Justine K., Hein, Nadine, Poh, Perlita, Wysoke, Kira D., Williams, Tobias D., Montellese, Christian, Smith, Lorey K., Al-Obaidi, Sheren J., Núñez-Villacís, Lorena, Pavy, Megan, He, Jin-Shu, Parsons, Kate M., Loring, Karagh E., Morrison, Tess, Diesch, Jeannine, Burgio, Gaetan, Ferreira, Rita, Feng, Zhi-Ping, Gould, Cathryn M., Madhamshettiwar, Piyush B., Flygare, Johan, Gonda, Thomas J., Simpson, Kaylene J., Kutay, Ulrike, Pearson, Richard B., Engel, Christoph, Watkins, Nicholas J., Hannan, Ross D., George, Amee J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647041/
https://www.ncbi.nlm.nih.gov/pubmed/36323262
http://dx.doi.org/10.1016/j.celrep.2022.111571

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