Targeting transmembrane-domain-less MOG expression to platelets prevents disease development in experimental autoimmune encephalomyelitis

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system with no cure yet. Here, we report genetic engineering of hematopoietic stem cells (HSCs) to express myelin oligodendrocyte glycoprotein (MOG), specifically in platelets, as a means of intervention to i...

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Detalles Bibliográficos
Autores principales: Cai, Yuanhua, Schroeder, Jocelyn A., Jing, Weiqing, Gurski, Cody, Williams, Calvin B., Wang, Shaoyuan, Dittel, Bonnie N., Shi, Qizhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647046/
https://www.ncbi.nlm.nih.gov/pubmed/36389708
http://dx.doi.org/10.3389/fimmu.2022.1029356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647046/
https://www.ncbi.nlm.nih.gov/pubmed/36389708
http://dx.doi.org/10.3389/fimmu.2022.1029356

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