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A Lethal Manifestation of Chronic Active Epstein-Barr Virus Infection: A Case Report

Chronic active Epstein-Barr virus infection (CAEBV) is a rare and lethal condition caused by persistent Epstein-Barr virus (EBV) infection. Signs and symptoms of CAEBV infection include fever, lymphadenopathy, and hepatosplenomegaly. Due to life-threatening consequences such as multiple organ failur...

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Autores principales: Alotaibi, Yousef, Albogami, Mahdi, Alsaedy, Abdulrahman, Khubrani, Rashed, Al Ahmadi, Bushra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647082/
https://www.ncbi.nlm.nih.gov/pubmed/36397893
http://dx.doi.org/10.7759/cureus.30158
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author Alotaibi, Yousef
Albogami, Mahdi
Alsaedy, Abdulrahman
Khubrani, Rashed
Al Ahmadi, Bushra
author_facet Alotaibi, Yousef
Albogami, Mahdi
Alsaedy, Abdulrahman
Khubrani, Rashed
Al Ahmadi, Bushra
author_sort Alotaibi, Yousef
collection PubMed
description Chronic active Epstein-Barr virus infection (CAEBV) is a rare and lethal condition caused by persistent Epstein-Barr virus (EBV) infection. Signs and symptoms of CAEBV infection include fever, lymphadenopathy, and hepatosplenomegaly. Due to life-threatening consequences such as multiple organ failure, hemophagocytic syndrome, EBV-positive lymphoproliferative illness, and coagulopathy, early identification is important for successful therapy. However, because of the wide range of clinical symptoms, it might be difficult to diagnose the disease due to limited clinical experience and a low number of reports. We report a case of CAEBV in a 59-year-old woman from Saudi Arabia. We present the hospital course of the patient from admission until the patient's death as well as the clinical and pathological findings with a review of the literature. This is a rare case of CAEBV in Saudi Arabia.
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spelling pubmed-96470822022-11-16 A Lethal Manifestation of Chronic Active Epstein-Barr Virus Infection: A Case Report Alotaibi, Yousef Albogami, Mahdi Alsaedy, Abdulrahman Khubrani, Rashed Al Ahmadi, Bushra Cureus Internal Medicine Chronic active Epstein-Barr virus infection (CAEBV) is a rare and lethal condition caused by persistent Epstein-Barr virus (EBV) infection. Signs and symptoms of CAEBV infection include fever, lymphadenopathy, and hepatosplenomegaly. Due to life-threatening consequences such as multiple organ failure, hemophagocytic syndrome, EBV-positive lymphoproliferative illness, and coagulopathy, early identification is important for successful therapy. However, because of the wide range of clinical symptoms, it might be difficult to diagnose the disease due to limited clinical experience and a low number of reports. We report a case of CAEBV in a 59-year-old woman from Saudi Arabia. We present the hospital course of the patient from admission until the patient's death as well as the clinical and pathological findings with a review of the literature. This is a rare case of CAEBV in Saudi Arabia. Cureus 2022-10-10 /pmc/articles/PMC9647082/ /pubmed/36397893 http://dx.doi.org/10.7759/cureus.30158 Text en Copyright © 2022, Alotaibi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Alotaibi, Yousef
Albogami, Mahdi
Alsaedy, Abdulrahman
Khubrani, Rashed
Al Ahmadi, Bushra
A Lethal Manifestation of Chronic Active Epstein-Barr Virus Infection: A Case Report
title A Lethal Manifestation of Chronic Active Epstein-Barr Virus Infection: A Case Report
title_full A Lethal Manifestation of Chronic Active Epstein-Barr Virus Infection: A Case Report
title_fullStr A Lethal Manifestation of Chronic Active Epstein-Barr Virus Infection: A Case Report
title_full_unstemmed A Lethal Manifestation of Chronic Active Epstein-Barr Virus Infection: A Case Report
title_short A Lethal Manifestation of Chronic Active Epstein-Barr Virus Infection: A Case Report
title_sort lethal manifestation of chronic active epstein-barr virus infection: a case report
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647082/
https://www.ncbi.nlm.nih.gov/pubmed/36397893
http://dx.doi.org/10.7759/cureus.30158
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