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Cryoablation and immune synergistic effect for lung cancer: A review

The preferred treatment for lung cancer is surgical resection, but a large number of patients are not suitable for surgical resection in clinic. CT-guided cryoablation and immunotherapy can play an important role in patients with advanced lung cancer who are ineligible for surgery. CT-guided cryoabl...

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Autores principales: Tian, Yulong, Qi, Xingshun, Jiang, Xin, Shang, Liqi, Xu, Ke, Shao, Haibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647087/
https://www.ncbi.nlm.nih.gov/pubmed/36389781
http://dx.doi.org/10.3389/fimmu.2022.950921
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author Tian, Yulong
Qi, Xingshun
Jiang, Xin
Shang, Liqi
Xu, Ke
Shao, Haibo
author_facet Tian, Yulong
Qi, Xingshun
Jiang, Xin
Shang, Liqi
Xu, Ke
Shao, Haibo
author_sort Tian, Yulong
collection PubMed
description The preferred treatment for lung cancer is surgical resection, but a large number of patients are not suitable for surgical resection in clinic. CT-guided cryoablation and immunotherapy can play an important role in patients with advanced lung cancer who are ineligible for surgery. CT-guided cryoablation has been widely used in the clinical treatment of lung tumors due to its advantages of less trauma, fewer complications, significant efficacy and rapid recovery. Cryoablation can not only cause tumor necrosis and apoptosis, but also promote the release of tumor-derived autoantigens into the blood circulation, and stimulate the host immune system to produce a good anti-tumor immune effect against primary and metastatic tumors. Since the study of immune checkpoint inhibitors has proved that lung cancer can be an immunotherapeutic response disease, the relationship between cryoablation and immunotherapy of lung cancer has been paid more attention. Therefore, we reviewed the literature on cryoablation for lung cancer, as well as the research progress of cryoablation combined with immunotherapy.
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spelling pubmed-96470872022-11-15 Cryoablation and immune synergistic effect for lung cancer: A review Tian, Yulong Qi, Xingshun Jiang, Xin Shang, Liqi Xu, Ke Shao, Haibo Front Immunol Immunology The preferred treatment for lung cancer is surgical resection, but a large number of patients are not suitable for surgical resection in clinic. CT-guided cryoablation and immunotherapy can play an important role in patients with advanced lung cancer who are ineligible for surgery. CT-guided cryoablation has been widely used in the clinical treatment of lung tumors due to its advantages of less trauma, fewer complications, significant efficacy and rapid recovery. Cryoablation can not only cause tumor necrosis and apoptosis, but also promote the release of tumor-derived autoantigens into the blood circulation, and stimulate the host immune system to produce a good anti-tumor immune effect against primary and metastatic tumors. Since the study of immune checkpoint inhibitors has proved that lung cancer can be an immunotherapeutic response disease, the relationship between cryoablation and immunotherapy of lung cancer has been paid more attention. Therefore, we reviewed the literature on cryoablation for lung cancer, as well as the research progress of cryoablation combined with immunotherapy. Frontiers Media S.A. 2022-10-27 /pmc/articles/PMC9647087/ /pubmed/36389781 http://dx.doi.org/10.3389/fimmu.2022.950921 Text en Copyright © 2022 Tian, Qi, Jiang, Shang, Xu and Shao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Tian, Yulong
Qi, Xingshun
Jiang, Xin
Shang, Liqi
Xu, Ke
Shao, Haibo
Cryoablation and immune synergistic effect for lung cancer: A review
title Cryoablation and immune synergistic effect for lung cancer: A review
title_full Cryoablation and immune synergistic effect for lung cancer: A review
title_fullStr Cryoablation and immune synergistic effect for lung cancer: A review
title_full_unstemmed Cryoablation and immune synergistic effect for lung cancer: A review
title_short Cryoablation and immune synergistic effect for lung cancer: A review
title_sort cryoablation and immune synergistic effect for lung cancer: a review
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647087/
https://www.ncbi.nlm.nih.gov/pubmed/36389781
http://dx.doi.org/10.3389/fimmu.2022.950921
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