Cargando…

Emerging target discovery and drug repurposing opportunities in chordoma

The development of effective and personalized treatment options for patients with rare cancers like chordoma is hampered by numerous challenges. Biomarker-guided repurposing of therapies approved in other indications remains the fastest path to redefining the treatment paradigm, but chordoma’s low m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Freed, Daniel M., Sommer, Josh, Punturi, Nindo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647139/ https://www.ncbi.nlm.nih.gov/pubmed/36387127 http://dx.doi.org/10.3389/fonc.2022.1009193

Ejemplares similares

Identification of repurposed small molecule drugs for chordoma therapy
por: Xia, Menghang, et al.
Publicado: (2013)

New opportunities for kinase drug repurposing and target discovery
por: Knapp, Stefan
Publicado: (2018)

Editorial: Biological aspects of targeted drug discovery: Development of novel targets and/or chemotherapies, and drug repurposing
por: Kalra, Rajkumar Singh, et al.
Publicado: (2022)

Synergistic drug combinations and machine learning for drug repurposing in chordoma
por: Anderson, Edward, et al.
Publicado: (2020)

Computational approaches for drug repurposing in oncology: untapped opportunity for high value innovation
por: Dalwadi, Shraddha M., et al.
Publicado: (2023)

Prediction and Identification of GPCRs Targeting for Drug Repurposing in Osteosarcoma
por: Tan, Manli, et al.
Publicado: (2022)

Personalized chordoma organoids for drug discovery studies
por: Al Shihabi, Ahmad, et al.
Publicado: (2022)

Molecular Targeted Therapy in the Treatment of Chordoma: A Systematic Review
por: Meng, Tong, et al.
Publicado: (2019)

Selinexor inhibits growth of patient derived chordomas in vivo as a single agent and in combination with abemaciclib through diverse mechanisms
por: Walker, Christopher J., et al.
Publicado: (2022)

Drug Repurposing by Tumor Tissue Editing
por: Lüke, Florian, et al.
Publicado: (2022)

Kidney Cancer Models for Pre-Clinical Drug Discovery: Challenges and Opportunities
por: Pohl, Laura, et al.
Publicado: (2022)

Mapping the landscape of genetic dependencies in chordoma
por: Sharifnia, Tanaz, et al.
Publicado: (2023)

Editorial: Chordoma: advances in biology and clinical management
por: Gardner, Paul, et al.
Publicado: (2023)

Activity of pemetrexed in pre-clinical chordoma models and humans
por: Kesari, Santosh, et al.
Publicado: (2023)

Repurposing of Drug Candidates for Treatment of Skin Cancer
por: Cortés, Hernán, et al.
Publicado: (2021)

B7-H3 as a Target for CAR-T Cell Therapy in Skull Base Chordoma
por: Long, Cheng, et al.
Publicado: (2021)

Targeted Drug Discovery for Pediatric Leukemia
por: Napper, Andrew D., et al.
Publicado: (2013)

Research hotspots and trends of chordoma: A bibliometric analysis
por: Gao, Jianxuan, et al.
Publicado: (2022)

Anthelmintics for drug repurposing: Opportunities and challenges
por: Alavi, Seyed Ebrahim, et al.
Publicado: (2021)

Target-specific compound selectivity for multi-target drug discovery and repurposing
por: Wang, Tianduanyi, et al.
Publicado: (2022)

Editorial: Repurposed Drugs Targeting Cancer Signaling Pathways: Clinical Insights to Improve Oncologic Therapies
por: Pérez-Plasencia, Carlos, et al.
Publicado: (2021)

Clinicopathological and Prognostic Characteristics in Dedifferentiated/Poorly Differentiated Chordomas: A Pooled Analysis of Individual Patient Data From 58 Studies and Comparison With Conventional Chordomas
por: Liu, Fu-Sheng, et al.
Publicado: (2021)

Deubiquitylating enzymes and drug discovery: emerging opportunities
por: Harrigan, Jeanine A., et al.
Publicado: (2017)

Circulating tumor DNA – A potential aid in the management of chordomas
por: Frederico, Stephen C., et al.
Publicado: (2022)

Methylation-based reclassification and risk stratification of skull-base chordomas
por: Huo, Xulei, et al.
Publicado: (2022)

The Surgical Approach Combined With Minimally Invasive Surgery for Sacral Chordoma
por: Garcia Mora, Mauricio, et al.
Publicado: (2021)

The role of Gamma Knife radiosurgery in the management of skull base chordoma
por: Wang, Kuanyu, et al.
Publicado: (2023)

The druggable schizophrenia genome: from repurposing opportunities to unexplored drug targets
por: Lago, Santiago G., et al.
Publicado: (2022)

Drug Repurposing Opportunities in Pancreatic Ductal Adenocarcinoma
por: Rebelo, Rita, et al.
Publicado: (2021)

COVID-19: molecular targets, drug repurposing and new avenues for drug discovery
por: Senger, Mario Roberto, et al.
Publicado: (2020)

Off-target based drug repurposing opportunities for tivantinib in acute myeloid leukemia
por: Kuenzi, Brent M., et al.
Publicado: (2019)

Durable Response of Spinal Chordoma to Combined Inhibition of IGF-1R and EGFR
por: Aleksic, Tamara, et al.
Publicado: (2016)

Biomarker-Guided Repurposing of Chemotherapeutic Drugs for Cancer Therapy: A Novel Strategy in Drug Development
por: Stenvang, Jan, et al.
Publicado: (2013)

Drug Repurposing: An Effective Tool in Modern Drug Discovery
por: Kulkarni, V. S., et al.
Publicado: (2023)

Pathway-Based Drug-Repurposing Schemes in Cancer: The Role of Translational Bioinformatics
por: Hernández-Lemus, Enrique, et al.
Publicado: (2021)

Editorial: Repurposed Drugs Targeting Cancer Signaling Pathways: Dissecting New Mechanism of Action Through In Vitro and In Vivo Analyses
por: López-Urrutia, Eduardo, et al.
Publicado: (2021)

Intraoperative Magnetic Resonance Imaging Assisted Endoscopic Endonasal Resection of Clival Chordomas
por: Gulsuna, Beste, et al.
Publicado: (2022)

A correlation analysis of sacrococcygeal chordoma imaging and clinical characteristics with the prognostic factors
por: Zhao, Fei, et al.
Publicado: (2022)

PALB2 as a factor to predict the prognosis of patients with skull base chordoma
por: Xiong, Yujia, et al.
Publicado: (2022)

High systemic inflammation score is associated with adverse survival in skull base chordoma
por: Li, Mingxuan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_roc547tfvb633e5orqau005lj8