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Kidney in VHL disease: Early clear cell proliferation occurs in the distal tubular system
Renal clear cell carcinoma commonly occurs in patients with von Hippel-Lindau disease (VHL). Kidneys of VHL disease patients (VHL kidneys) contain an abundance of independent clear cell proliferation events that have been hypothesized to represent precursor structures of clear cell carcinoma. In the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647499/ https://www.ncbi.nlm.nih.gov/pubmed/36321775 http://dx.doi.org/10.3892/or.2022.8437 |
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author | Al-Gharaibeh, Nayef S. Temm, Constance J. Shively, Sharon B. Vortmeyer, Alexander O. |
author_facet | Al-Gharaibeh, Nayef S. Temm, Constance J. Shively, Sharon B. Vortmeyer, Alexander O. |
author_sort | Al-Gharaibeh, Nayef S. |
collection | PubMed |
description | Renal clear cell carcinoma commonly occurs in patients with von Hippel-Lindau disease (VHL). Kidneys of VHL disease patients (VHL kidneys) contain an abundance of independent clear cell proliferation events that have been hypothesized to represent precursor structures of clear cell carcinoma. In the present study, it was tried to identify the site of origin of clear cell proliferation, and the immunophenotype of clear cells. Using 3D histological tracking, the topographic origin of microscopic clear cell proliferation was investigated by identification of informative structures of interest and immunohistochemical staining for cluster of differentiation 10 (CD10) and cytokeratin 7 (CK7) in consecutive serial sections. In addition, the CD10/CK7 immunophenotype of proliferating clear cells was evaluated. Clear cell proliferation uniformly occurred in the distal tubular system. Some clear cell proliferation, however, revealed proximal tubule immunophenotype. It was concluded that early proliferation of VHL-deficient clear cells occurs in the distal tubular system. Despite the association with the distal tubular system, the immunohistochemical profile of early clear cell proliferation may be inconsistent with its distal tubular origin. |
format | Online Article Text |
id | pubmed-9647499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-96474992022-11-22 Kidney in VHL disease: Early clear cell proliferation occurs in the distal tubular system Al-Gharaibeh, Nayef S. Temm, Constance J. Shively, Sharon B. Vortmeyer, Alexander O. Oncol Rep Articles Renal clear cell carcinoma commonly occurs in patients with von Hippel-Lindau disease (VHL). Kidneys of VHL disease patients (VHL kidneys) contain an abundance of independent clear cell proliferation events that have been hypothesized to represent precursor structures of clear cell carcinoma. In the present study, it was tried to identify the site of origin of clear cell proliferation, and the immunophenotype of clear cells. Using 3D histological tracking, the topographic origin of microscopic clear cell proliferation was investigated by identification of informative structures of interest and immunohistochemical staining for cluster of differentiation 10 (CD10) and cytokeratin 7 (CK7) in consecutive serial sections. In addition, the CD10/CK7 immunophenotype of proliferating clear cells was evaluated. Clear cell proliferation uniformly occurred in the distal tubular system. Some clear cell proliferation, however, revealed proximal tubule immunophenotype. It was concluded that early proliferation of VHL-deficient clear cells occurs in the distal tubular system. Despite the association with the distal tubular system, the immunohistochemical profile of early clear cell proliferation may be inconsistent with its distal tubular origin. D.A. Spandidos 2022-11-01 /pmc/articles/PMC9647499/ /pubmed/36321775 http://dx.doi.org/10.3892/or.2022.8437 Text en Copyright: © Al-Gharaibeh et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Al-Gharaibeh, Nayef S. Temm, Constance J. Shively, Sharon B. Vortmeyer, Alexander O. Kidney in VHL disease: Early clear cell proliferation occurs in the distal tubular system |
title | Kidney in VHL disease: Early clear cell proliferation occurs in the distal tubular system |
title_full | Kidney in VHL disease: Early clear cell proliferation occurs in the distal tubular system |
title_fullStr | Kidney in VHL disease: Early clear cell proliferation occurs in the distal tubular system |
title_full_unstemmed | Kidney in VHL disease: Early clear cell proliferation occurs in the distal tubular system |
title_short | Kidney in VHL disease: Early clear cell proliferation occurs in the distal tubular system |
title_sort | kidney in vhl disease: early clear cell proliferation occurs in the distal tubular system |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647499/ https://www.ncbi.nlm.nih.gov/pubmed/36321775 http://dx.doi.org/10.3892/or.2022.8437 |
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