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Computational and functional studies of the PI(4,5)P(2) binding site of the TRPM3 ion channel reveal interactions with other regulators

Transient receptor potential melastatin 3 (TRPM3) is a heat-activated ion channel expressed in peripheral sensory neurons and the central nervous system. TRPM3 activity depends on the membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)), but the molecular mechanism of activation...

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Detalles Bibliográficos
Autores principales:	Zhao, Siyuan, Carnevale, Vincenzo, Gabrielle, Matthew, Gianti, Eleonora, Rohacs, Tibor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647539/ https://www.ncbi.nlm.nih.gov/pubmed/36181791 http://dx.doi.org/10.1016/j.jbc.2022.102547

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