Aging-associated REGγ proteasome decline predisposes to tauopathy

The REGγ-20S proteasome is an ubiquitin- and ATP-independent degradation system, targeting selective substrates, possibly helping to regulate aging. The studies we report here demonstrate that aging-associated REGγ decline predisposes to decreasing tau turnover, as in a tauopathy. The REGγ proteasom...

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Detalles Bibliográficos
Autores principales: Tu, Jialu, Zhang, Haiyang, Yang, Ting, Liu, Yun, Kibreab, Solomon, Zhang, Yunpeng, Gao, Liangcai, Moses, Robb E., O'Malley, Bert W., Xiao, Jianru, Li, Xiaotao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647549/
https://www.ncbi.nlm.nih.gov/pubmed/36209822
http://dx.doi.org/10.1016/j.jbc.2022.102571

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