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Dietary sodium restriction prevents vascular endothelial growth factor inhibitor-induced hypertension

BACKGROUND: Vascular endothelial growth factor inhibitors (VEGFIs) are effective anticancer agents which often induce hypertension. VEGFI-induced hypertension is sodium-sensitive in animal studies. Therefore, the efficacy of dietary sodium restriction (DSR) to prevent VEGFI-induced hypertension in c...

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Autores principales: van Doorn, Leni, Visser, Wesley J., van Dorst, Daan C. H., Mirabito Colafella, Katrina M., Koolen, Stijn L. W., de Mik, Anneke van Egmond-, Garrelds, Ingrid M., Bovée, Dominique M., de Hoop, Esther Oomen-, Bins, Sander, Eskens, Ferry A. L. M., Hoorn, Ewout J., Jan Danser, A. H., Mathijssen, Ron H. J., Versmissen, Jorie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647750/
https://www.ncbi.nlm.nih.gov/pubmed/36357702
http://dx.doi.org/10.1038/s41416-022-02036-6
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author van Doorn, Leni
Visser, Wesley J.
van Dorst, Daan C. H.
Mirabito Colafella, Katrina M.
Koolen, Stijn L. W.
de Mik, Anneke van Egmond-
Garrelds, Ingrid M.
Bovée, Dominique M.
de Hoop, Esther Oomen-
Bins, Sander
Eskens, Ferry A. L. M.
Hoorn, Ewout J.
Jan Danser, A. H.
Mathijssen, Ron H. J.
Versmissen, Jorie
author_facet van Doorn, Leni
Visser, Wesley J.
van Dorst, Daan C. H.
Mirabito Colafella, Katrina M.
Koolen, Stijn L. W.
de Mik, Anneke van Egmond-
Garrelds, Ingrid M.
Bovée, Dominique M.
de Hoop, Esther Oomen-
Bins, Sander
Eskens, Ferry A. L. M.
Hoorn, Ewout J.
Jan Danser, A. H.
Mathijssen, Ron H. J.
Versmissen, Jorie
author_sort van Doorn, Leni
collection PubMed
description BACKGROUND: Vascular endothelial growth factor inhibitors (VEGFIs) are effective anticancer agents which often induce hypertension. VEGFI-induced hypertension is sodium-sensitive in animal studies. Therefore, the efficacy of dietary sodium restriction (DSR) to prevent VEGFI-induced hypertension in cancer patients was studied. METHODS: Cancer patients with VEGFI-induced hypertension (day mean >135/85 mmHg or a rise in systolic and/or diastolic BP ≥ 20 mmHg) were treated with DSR (aiming at <4 g salt/day). The primary endpoint was the difference in daytime mean arterial blood pressure (MAP) increase between the treatment cycle with and without DSR. RESULTS: During the first VEGFI treatment cycle without DSR, mean daytime MAP increased from 95 to 110 mmHg. During the subsequent treatment cycle with DSR, mean daytime MAP increased from 94 to 102 mmHg. Therefore, DSR attenuated the increase in mean daytime MAP by 7 mmHg (95% CI 1.3–12.0, P = 0.009). DSR prevented the rise in the endothelin-1/renin ratio that normally accompanies VEGFI-induced hypertension (P = 0.020) and prevented the onset of proteinuria: 0.15 (0.10–0.25) g/24 h with DSR versus 0.19 (0.11–0.32) g/24 h without DSR; P = 0.005. DISCUSSION: DSR significantly attenuated VEGFI induced BP rise and proteinuria and thus is an effective non-pharmacological intervention.
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spelling pubmed-96477502022-11-14 Dietary sodium restriction prevents vascular endothelial growth factor inhibitor-induced hypertension van Doorn, Leni Visser, Wesley J. van Dorst, Daan C. H. Mirabito Colafella, Katrina M. Koolen, Stijn L. W. de Mik, Anneke van Egmond- Garrelds, Ingrid M. Bovée, Dominique M. de Hoop, Esther Oomen- Bins, Sander Eskens, Ferry A. L. M. Hoorn, Ewout J. Jan Danser, A. H. Mathijssen, Ron H. J. Versmissen, Jorie Br J Cancer Article BACKGROUND: Vascular endothelial growth factor inhibitors (VEGFIs) are effective anticancer agents which often induce hypertension. VEGFI-induced hypertension is sodium-sensitive in animal studies. Therefore, the efficacy of dietary sodium restriction (DSR) to prevent VEGFI-induced hypertension in cancer patients was studied. METHODS: Cancer patients with VEGFI-induced hypertension (day mean >135/85 mmHg or a rise in systolic and/or diastolic BP ≥ 20 mmHg) were treated with DSR (aiming at <4 g salt/day). The primary endpoint was the difference in daytime mean arterial blood pressure (MAP) increase between the treatment cycle with and without DSR. RESULTS: During the first VEGFI treatment cycle without DSR, mean daytime MAP increased from 95 to 110 mmHg. During the subsequent treatment cycle with DSR, mean daytime MAP increased from 94 to 102 mmHg. Therefore, DSR attenuated the increase in mean daytime MAP by 7 mmHg (95% CI 1.3–12.0, P = 0.009). DSR prevented the rise in the endothelin-1/renin ratio that normally accompanies VEGFI-induced hypertension (P = 0.020) and prevented the onset of proteinuria: 0.15 (0.10–0.25) g/24 h with DSR versus 0.19 (0.11–0.32) g/24 h without DSR; P = 0.005. DISCUSSION: DSR significantly attenuated VEGFI induced BP rise and proteinuria and thus is an effective non-pharmacological intervention. Nature Publishing Group UK 2022-11-10 2023-01-19 /pmc/articles/PMC9647750/ /pubmed/36357702 http://dx.doi.org/10.1038/s41416-022-02036-6 Text en © The Author(s), under exclusive licence to Springer Nature Limited 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
spellingShingle Article
van Doorn, Leni
Visser, Wesley J.
van Dorst, Daan C. H.
Mirabito Colafella, Katrina M.
Koolen, Stijn L. W.
de Mik, Anneke van Egmond-
Garrelds, Ingrid M.
Bovée, Dominique M.
de Hoop, Esther Oomen-
Bins, Sander
Eskens, Ferry A. L. M.
Hoorn, Ewout J.
Jan Danser, A. H.
Mathijssen, Ron H. J.
Versmissen, Jorie
Dietary sodium restriction prevents vascular endothelial growth factor inhibitor-induced hypertension
title Dietary sodium restriction prevents vascular endothelial growth factor inhibitor-induced hypertension
title_full Dietary sodium restriction prevents vascular endothelial growth factor inhibitor-induced hypertension
title_fullStr Dietary sodium restriction prevents vascular endothelial growth factor inhibitor-induced hypertension
title_full_unstemmed Dietary sodium restriction prevents vascular endothelial growth factor inhibitor-induced hypertension
title_short Dietary sodium restriction prevents vascular endothelial growth factor inhibitor-induced hypertension
title_sort dietary sodium restriction prevents vascular endothelial growth factor inhibitor-induced hypertension
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647750/
https://www.ncbi.nlm.nih.gov/pubmed/36357702
http://dx.doi.org/10.1038/s41416-022-02036-6
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