ATRA-induced bradycardia in a case of acute promyelocytic leukemia: A case report

A 45-year-old female, a new case of acute promyelocytic leukemia (APL), received induction chemotherapy containing all-trans retinoic acid (ATRA) and idarubicin. On the sixth day of therapy, she developed sinus bradycardia and differentiation syndrome (DS). Electrolytes and cardiac imaging were norm...

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Detalles Bibliográficos
Autores principales: Rathod, Santosh Govind, Khan, Afaq Ahmad, Geelani, Sajad Ahmed, Roshan, Reshma, Bhat, Javid Rasool
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648224/
https://www.ncbi.nlm.nih.gov/pubmed/36387725
http://dx.doi.org/10.4103/jfmpc.jfmpc_1663_21
Descripción
Sumario:A 45-year-old female, a new case of acute promyelocytic leukemia (APL), received induction chemotherapy containing all-trans retinoic acid (ATRA) and idarubicin. On the sixth day of therapy, she developed sinus bradycardia and differentiation syndrome (DS). Electrolytes and cardiac imaging were normal. The patient achieved normal sinus rhythm after ATRA was withheld, and DS was treated.

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