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Is perinatal asphyxia associated with an increase in serum bilirubin in neonates? A case-control study

OBJECTIVE: Perinatal asphyxia affects different organs of body depending upon the severity of hypoxemia and ischemia. This study was carried out to evaluate severity of hyperbilirubinemia in relation to severity of asphyxia. STUDY DESIGN: A case-control study. METHODOLOGY: Asphyxiated newborns with...

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Autores principales: Rai, Seema, Sood, Mangla, Kaur, Amarpreet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648229/
https://www.ncbi.nlm.nih.gov/pubmed/36387686
http://dx.doi.org/10.4103/jfmpc.jfmpc_1018_21
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author Rai, Seema
Sood, Mangla
Kaur, Amarpreet
author_facet Rai, Seema
Sood, Mangla
Kaur, Amarpreet
author_sort Rai, Seema
collection PubMed
description OBJECTIVE: Perinatal asphyxia affects different organs of body depending upon the severity of hypoxemia and ischemia. This study was carried out to evaluate severity of hyperbilirubinemia in relation to severity of asphyxia. STUDY DESIGN: A case-control study. METHODOLOGY: Asphyxiated newborns with Apgar score ≤7 at 1 min. and categorized as severe birth asphyxia according to the WHO classification of diseases (ICD10) were matched with controls without birth asphyxia. All babies were examined twice daily for dermal icterus until start of phototherapy. Babies with congenital heart disease, sepsis, cephalohematoma, blood group incompatibility were excluded. Arterial blood gas analysis was done along with serial TSB measurement as per standard guidelines. RESULTS: 50 cases and 50 matched controls were enrolled. The average birth weight and gestation in cases was 2427 ± 30.05 g and 35.9 ± 2.5 weeks and among control it was 2633 ± 378.62 g and 37.76 ± 0.116 weeks. Among cases, onset of jaundice was 56.64 ± 20.43 h compared to 63.36 ± 23 h in control group. In the cases, the average pH was 7.31 ± 0.06, CO(2) was 41.52 ± 84, O(2) was 94.98 ± 14.83, and HCO(3) was 18.56 ± 2.04. The rise and peak of serum bilirubin differed between the case and control groups; in the cases, the peak occurred at the 22(nd) h of life, then plateaued from the 40(th) to the 78(th) hour of life, and ultimately fell at the 96(th) hour of life. In comparison, the rise and peak of serum bilirubin occurred comparatively late in the control group. The rise and peak in the control group occurred at the 80(th) and 96(th) h of life, respectively. The multiple linear regression analysis showed CRP, Apgar at 5 min. below 7 and male gender significantly affects the rise of serum bilirubin (P < 0.05). CONCLUSION: The peak serum bilirubin in asphyxiated newborns occurs earlier, and plateau for longer duration compared to normal newborns. Low Apgar at 5 min. has significant correlation to earlier rise of bilirubin.
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spelling pubmed-96482292022-11-15 Is perinatal asphyxia associated with an increase in serum bilirubin in neonates? A case-control study Rai, Seema Sood, Mangla Kaur, Amarpreet J Family Med Prim Care Original Article OBJECTIVE: Perinatal asphyxia affects different organs of body depending upon the severity of hypoxemia and ischemia. This study was carried out to evaluate severity of hyperbilirubinemia in relation to severity of asphyxia. STUDY DESIGN: A case-control study. METHODOLOGY: Asphyxiated newborns with Apgar score ≤7 at 1 min. and categorized as severe birth asphyxia according to the WHO classification of diseases (ICD10) were matched with controls without birth asphyxia. All babies were examined twice daily for dermal icterus until start of phototherapy. Babies with congenital heart disease, sepsis, cephalohematoma, blood group incompatibility were excluded. Arterial blood gas analysis was done along with serial TSB measurement as per standard guidelines. RESULTS: 50 cases and 50 matched controls were enrolled. The average birth weight and gestation in cases was 2427 ± 30.05 g and 35.9 ± 2.5 weeks and among control it was 2633 ± 378.62 g and 37.76 ± 0.116 weeks. Among cases, onset of jaundice was 56.64 ± 20.43 h compared to 63.36 ± 23 h in control group. In the cases, the average pH was 7.31 ± 0.06, CO(2) was 41.52 ± 84, O(2) was 94.98 ± 14.83, and HCO(3) was 18.56 ± 2.04. The rise and peak of serum bilirubin differed between the case and control groups; in the cases, the peak occurred at the 22(nd) h of life, then plateaued from the 40(th) to the 78(th) hour of life, and ultimately fell at the 96(th) hour of life. In comparison, the rise and peak of serum bilirubin occurred comparatively late in the control group. The rise and peak in the control group occurred at the 80(th) and 96(th) h of life, respectively. The multiple linear regression analysis showed CRP, Apgar at 5 min. below 7 and male gender significantly affects the rise of serum bilirubin (P < 0.05). CONCLUSION: The peak serum bilirubin in asphyxiated newborns occurs earlier, and plateau for longer duration compared to normal newborns. Low Apgar at 5 min. has significant correlation to earlier rise of bilirubin. Wolters Kluwer - Medknow 2022-07 2022-07-22 /pmc/articles/PMC9648229/ /pubmed/36387686 http://dx.doi.org/10.4103/jfmpc.jfmpc_1018_21 Text en Copyright: © 2022 Journal of Family Medicine and Primary Care https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Rai, Seema
Sood, Mangla
Kaur, Amarpreet
Is perinatal asphyxia associated with an increase in serum bilirubin in neonates? A case-control study
title Is perinatal asphyxia associated with an increase in serum bilirubin in neonates? A case-control study
title_full Is perinatal asphyxia associated with an increase in serum bilirubin in neonates? A case-control study
title_fullStr Is perinatal asphyxia associated with an increase in serum bilirubin in neonates? A case-control study
title_full_unstemmed Is perinatal asphyxia associated with an increase in serum bilirubin in neonates? A case-control study
title_short Is perinatal asphyxia associated with an increase in serum bilirubin in neonates? A case-control study
title_sort is perinatal asphyxia associated with an increase in serum bilirubin in neonates? a case-control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648229/
https://www.ncbi.nlm.nih.gov/pubmed/36387686
http://dx.doi.org/10.4103/jfmpc.jfmpc_1018_21
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