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Plethora of adverse drug reactions in geriatric population receiving statin therapy for dyslipidaemia

BACKGROUND: Hyperlipidemia plays a major role in the pathogenesis of cardiovascular diseases (CVD). Statins are considered to be the most efficacious drugs in the management of hyperlipidemia and this class of drugs is most commonly prescribed for the treatment of hyperlipidemias. Although statin th...

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Autores principales: Padhye, Mugdha R., Yadav, Nikhil S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648274/
https://www.ncbi.nlm.nih.gov/pubmed/36387654
http://dx.doi.org/10.4103/jfmpc.jfmpc_2205_21
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author Padhye, Mugdha R.
Yadav, Nikhil S.
author_facet Padhye, Mugdha R.
Yadav, Nikhil S.
author_sort Padhye, Mugdha R.
collection PubMed
description BACKGROUND: Hyperlipidemia plays a major role in the pathogenesis of cardiovascular diseases (CVD). Statins are considered to be the most efficacious drugs in the management of hyperlipidemia and this class of drugs is most commonly prescribed for the treatment of hyperlipidemias. Although statin therapy has transformed the management of hyperlipidemia, it is associated with the skeletal muscle, neurological, and metabolic adverse effects. This study was conducted to evaluate the adverse effects of statin therapy in a geriatric population which may help in understanding whether these effects are dose-dependent. METHODS: The study was conducted on 200 patients receiving statin therapy (atorvastatin and rosuvastatin) for hyperlipidemias. They were divided into four groups depending on the prescribed dose of atorvastatin and rosuvastatin. All study subjects were followed up for 6 months. The adverse effects reported by them during the statin therapy were documented and analyzed. RESULTS: All patients reported adverse effects after the initiation of statin therapy. Headache and muscle symptoms were among the most commonly reported adverse effects. There was no serious adverse effect (SAE). None of the adverse effects led to the discontinuation of the statin therapy. CONCLUSION: The results of this study suggest that all patients receiving statin therapy experience one or more adverse effects during the therapy. The adverse effects were not found to be severe in the geriatric age group.
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spelling pubmed-96482742022-11-15 Plethora of adverse drug reactions in geriatric population receiving statin therapy for dyslipidaemia Padhye, Mugdha R. Yadav, Nikhil S. J Family Med Prim Care Original Article BACKGROUND: Hyperlipidemia plays a major role in the pathogenesis of cardiovascular diseases (CVD). Statins are considered to be the most efficacious drugs in the management of hyperlipidemia and this class of drugs is most commonly prescribed for the treatment of hyperlipidemias. Although statin therapy has transformed the management of hyperlipidemia, it is associated with the skeletal muscle, neurological, and metabolic adverse effects. This study was conducted to evaluate the adverse effects of statin therapy in a geriatric population which may help in understanding whether these effects are dose-dependent. METHODS: The study was conducted on 200 patients receiving statin therapy (atorvastatin and rosuvastatin) for hyperlipidemias. They were divided into four groups depending on the prescribed dose of atorvastatin and rosuvastatin. All study subjects were followed up for 6 months. The adverse effects reported by them during the statin therapy were documented and analyzed. RESULTS: All patients reported adverse effects after the initiation of statin therapy. Headache and muscle symptoms were among the most commonly reported adverse effects. There was no serious adverse effect (SAE). None of the adverse effects led to the discontinuation of the statin therapy. CONCLUSION: The results of this study suggest that all patients receiving statin therapy experience one or more adverse effects during the therapy. The adverse effects were not found to be severe in the geriatric age group. Wolters Kluwer - Medknow 2022-07 2022-07-22 /pmc/articles/PMC9648274/ /pubmed/36387654 http://dx.doi.org/10.4103/jfmpc.jfmpc_2205_21 Text en Copyright: © 2022 Journal of Family Medicine and Primary Care https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Padhye, Mugdha R.
Yadav, Nikhil S.
Plethora of adverse drug reactions in geriatric population receiving statin therapy for dyslipidaemia
title Plethora of adverse drug reactions in geriatric population receiving statin therapy for dyslipidaemia
title_full Plethora of adverse drug reactions in geriatric population receiving statin therapy for dyslipidaemia
title_fullStr Plethora of adverse drug reactions in geriatric population receiving statin therapy for dyslipidaemia
title_full_unstemmed Plethora of adverse drug reactions in geriatric population receiving statin therapy for dyslipidaemia
title_short Plethora of adverse drug reactions in geriatric population receiving statin therapy for dyslipidaemia
title_sort plethora of adverse drug reactions in geriatric population receiving statin therapy for dyslipidaemia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648274/
https://www.ncbi.nlm.nih.gov/pubmed/36387654
http://dx.doi.org/10.4103/jfmpc.jfmpc_2205_21
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