Identification of the first-in-class dual inhibitors of human DNA topoisomerase IIα and indoleamine-2,3-dioxygenase 1 (IDO 1) with strong anticancer properties

Molecular docking of a large set of thiosemicarbazide-based ligands resulted in obtaining compounds that inhibited both human DNA topoisomerase IIα and indoleamine-2,3-dioxygenase-1 (IDO1). To the best of our knowledge, these compounds are the first dual inhibitors targeting these two enzymes. As bo...

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Detalles Bibliográficos
Autores principales: Kaproń, Barbara, Płazińska, Anita, Płaziński, Wojciech, Plech, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648375/
https://www.ncbi.nlm.nih.gov/pubmed/36345785
http://dx.doi.org/10.1080/14756366.2022.2140420

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