Na(+)/H(+)-exchanger 1 Enhances Antitumor Activity of Engineered NK-92 Natural Killer Cells

Adoptive cell transfer (ACT) immunotherapy has remarkable efficacy against some hematologic malignancies. However, its efficacy in solid tumors is limited by the adverse tumor microenvironment (TME) conditions, most notably that acidity inhibits T and natural killer (NK) cell mTOR complex 1 (mTORC1)...

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Detalles Bibliográficos
Autores principales: Gong, Yao-Yu, Shao, Hongguang, Li, Yu, Brafford, Patricia, Stine, Zachary E., Sun, Jing, Felsher, Dean W., Orange, Jordan S., Albelda, Steven M., Dang, Chi V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648415/
https://www.ncbi.nlm.nih.gov/pubmed/36380966
http://dx.doi.org/10.1158/2767-9764.CRC-22-0270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648415/
https://www.ncbi.nlm.nih.gov/pubmed/36380966
http://dx.doi.org/10.1158/2767-9764.CRC-22-0270

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