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Long-lasting cognitive effects of COVID-19: is there a role of BDNF?
Coronavirus disease 2019 (COVID-19) affects numerous systems of the body during the illness, and there have been long-lasting effects. BDNF plays an important role in synaptic plasticity and synaptic communication. According to the inclusion and exclusion criteria, 54 patients who had COVID-19 infec...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648433/ https://www.ncbi.nlm.nih.gov/pubmed/36355087 http://dx.doi.org/10.1007/s00406-022-01514-5 |
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author | Demir, Biçem Beyazyüz, Elmas Beyazyüz, Murat Çelikkol, Aliye Albayrak, Yakup |
author_facet | Demir, Biçem Beyazyüz, Elmas Beyazyüz, Murat Çelikkol, Aliye Albayrak, Yakup |
author_sort | Demir, Biçem |
collection | PubMed |
description | Coronavirus disease 2019 (COVID-19) affects numerous systems of the body during the illness, and there have been long-lasting effects. BDNF plays an important role in synaptic plasticity and synaptic communication. According to the inclusion and exclusion criteria, 54 patients who had COVID-19 infection participated in this study. Thirty-six age-, sex-, body mass index (BMI)-, education level- and smoking status-matched healthy controls were included in the present study. All participants were individually administered the Stroop test and Visual Aural Digit Span Test Form B (VADS-B). Serum BDNF levels were measured by ELISA. Stroop test word reading spontaneous correction number and reading time, word color saying wrong number, spontaneous correction number and reading time, box color speaking spontaneous correction number and reading time, Stroop interference and speed factor duration were significantly higher in the COVID-19 group than in the control group. All scores of the VADS-B test were found to be significantly lower in the COVID-19 group. The mean serum BDNF levels were found to be 10.9 ± 6.9 ng/ml in the COVID-19 group and 12.8 ± 6.4 ng/ml in the healthy control group. Two-way ANOVA showed that the serum mean BDNF level was significantly lower in the COVID-19 group than in the control group. Gender had a significant effect on BDNF levels (F = 12.21; p = 0.008). The present study is the first to demonstrate the association between the role of serum BDNF and cognitive decline in patients with COVID-19 infection. Additionally, there is a significant role of male gender in terms of lower BDNF level and cognitive decline. |
format | Online Article Text |
id | pubmed-9648433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-96484332022-11-14 Long-lasting cognitive effects of COVID-19: is there a role of BDNF? Demir, Biçem Beyazyüz, Elmas Beyazyüz, Murat Çelikkol, Aliye Albayrak, Yakup Eur Arch Psychiatry Clin Neurosci Original Paper Coronavirus disease 2019 (COVID-19) affects numerous systems of the body during the illness, and there have been long-lasting effects. BDNF plays an important role in synaptic plasticity and synaptic communication. According to the inclusion and exclusion criteria, 54 patients who had COVID-19 infection participated in this study. Thirty-six age-, sex-, body mass index (BMI)-, education level- and smoking status-matched healthy controls were included in the present study. All participants were individually administered the Stroop test and Visual Aural Digit Span Test Form B (VADS-B). Serum BDNF levels were measured by ELISA. Stroop test word reading spontaneous correction number and reading time, word color saying wrong number, spontaneous correction number and reading time, box color speaking spontaneous correction number and reading time, Stroop interference and speed factor duration were significantly higher in the COVID-19 group than in the control group. All scores of the VADS-B test were found to be significantly lower in the COVID-19 group. The mean serum BDNF levels were found to be 10.9 ± 6.9 ng/ml in the COVID-19 group and 12.8 ± 6.4 ng/ml in the healthy control group. Two-way ANOVA showed that the serum mean BDNF level was significantly lower in the COVID-19 group than in the control group. Gender had a significant effect on BDNF levels (F = 12.21; p = 0.008). The present study is the first to demonstrate the association between the role of serum BDNF and cognitive decline in patients with COVID-19 infection. Additionally, there is a significant role of male gender in terms of lower BDNF level and cognitive decline. Springer Berlin Heidelberg 2022-11-10 /pmc/articles/PMC9648433/ /pubmed/36355087 http://dx.doi.org/10.1007/s00406-022-01514-5 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Original Paper Demir, Biçem Beyazyüz, Elmas Beyazyüz, Murat Çelikkol, Aliye Albayrak, Yakup Long-lasting cognitive effects of COVID-19: is there a role of BDNF? |
title | Long-lasting cognitive effects of COVID-19: is there a role of BDNF? |
title_full | Long-lasting cognitive effects of COVID-19: is there a role of BDNF? |
title_fullStr | Long-lasting cognitive effects of COVID-19: is there a role of BDNF? |
title_full_unstemmed | Long-lasting cognitive effects of COVID-19: is there a role of BDNF? |
title_short | Long-lasting cognitive effects of COVID-19: is there a role of BDNF? |
title_sort | long-lasting cognitive effects of covid-19: is there a role of bdnf? |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648433/ https://www.ncbi.nlm.nih.gov/pubmed/36355087 http://dx.doi.org/10.1007/s00406-022-01514-5 |
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