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Intranasal delivery of a rationally attenuated SARS-CoV-2 is immunogenic and protective in Syrian hamsters

Few live attenuated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are in pre-clinical or clinical development. We seek to attenuate SARS-CoV-2 (isolate WA1/2020) by removing the polybasic insert within the spike protein and the open reading frames (ORFs) 6–8, and by introduci...

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Detalles Bibliográficos
Autores principales:	Liu, Shufeng, Stauft, Charles B., Selvaraj, Prabhuanand, Chandrasekaran, Prabha, D’Agnillo, Felice, Chou, Chao-Kai, Wu, Wells W., Lien, Christopher Z., Meseda, Clement A., Pedro, Cyntia L., Starost, Matthew F., Weir, Jerry P., Wang, Tony T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648440/ https://www.ncbi.nlm.nih.gov/pubmed/36357440 http://dx.doi.org/10.1038/s41467-022-34571-4

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