Ferritin triggers neutrophil extracellular trap-mediated cytokine storm through Msr1 contributing to adult-onset Still’s disease pathogenesis

Hyperferritinemic syndrome, an overwhelming inflammatory condition, is characterized by high ferritin levels, systemic inflammation and multi-organ dysfunction, but the pathogenic role of ferritin remains largely unknown. Here we show in an animal model that ferritin administration leads to systemic...

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Detalles Bibliográficos
Autores principales: Jia, Jinchao, Wang, Mengyan, Meng, Jianfen, Ma, Yuning, Wang, Yang, Miao, Naijun, Teng, Jialin, Zhu, Dehao, Shi, Hui, Sun, Yue, Liu, Honglei, Cheng, Xiaobing, Su, Yutong, Ye, Junna, Chi, Huihui, Liu, Tingting, Zhou, Zhuochao, Wan, Liyan, Chen, Xia, Wang, Fan, Zhang, Hao, Ben, Jingjing, Wang, Jing, Yang, Chengde, Hu, Qiongyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648446/
https://www.ncbi.nlm.nih.gov/pubmed/36357401
http://dx.doi.org/10.1038/s41467-022-34560-7

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