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Age-related increase of alpha-synuclein oligomers is associated with motor disturbances in L61 transgenic mice

The pathogenesis of Parkinson’s disease involves fibrillization and deposition of alpha-synuclein (α-syn) into Lewy bodies. Accumulating evidence suggests that α-syn oligomers are particularly neurotoxic. Transgenic (tg) mice overexpressing wild-type human α-syn under the Thy-1 promoter (L61) reprod...

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Detalles Bibliográficos
Autores principales:	Roshanbin, Sahar, Aniszewska, Agata, Gumucio, Astrid, Masliah, Eliezer, Erlandsson, Anna, Bergström, Joakim, Ingelsson, Martin, Ekmark-Lewén, Sara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648497/ https://www.ncbi.nlm.nih.gov/pubmed/33639338 http://dx.doi.org/10.1016/j.neurobiolaging.2021.01.010

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