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Effect of nalbuphine on rocuronium injection pain

OBJECTIVE: Rocuronium-associated intravenous injection pain occurs frequently in children during induction of anesthesia. The aim of this study was to systematically evaluate the benefits of nalbuphine in patients with rocuronium-associated injection pain. METHODS: Ninety children undergoing tonsill...

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Detalles Bibliográficos
Autores principales: Huang, Wenfang, Huang, Jinjin, Wang, Dongpi, Hu, Yaoqin, Wang, Jiangmei, Lin, Hongfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648591/
https://www.ncbi.nlm.nih.gov/pubmed/36474974
http://dx.doi.org/10.1136/wjps-2020-000249
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author Huang, Wenfang
Huang, Jinjin
Wang, Dongpi
Hu, Yaoqin
Wang, Jiangmei
Lin, Hongfei
author_facet Huang, Wenfang
Huang, Jinjin
Wang, Dongpi
Hu, Yaoqin
Wang, Jiangmei
Lin, Hongfei
author_sort Huang, Wenfang
collection PubMed
description OBJECTIVE: Rocuronium-associated intravenous injection pain occurs frequently in children during induction of anesthesia. The aim of this study was to systematically evaluate the benefits of nalbuphine in patients with rocuronium-associated injection pain. METHODS: Ninety children undergoing tonsillectomy and adenoidectomy in our hospital between October 2019 and September 2020 were randomly divided into the following groups, with 30 patients per group: control group (group C), lidocaine group (group L), and nalbuphine group (group N). Routine 0.1 mg/kg midazolam and 2 mg/kg propofol were injected intravenously. After sedation, children in group C, group L, and group N were administered an intravenous injection of saline, lidocaine (10 mg/mL), or nalbuphine hydrochloride (2 mg/mL), respectively, at a dosage of 0.1 mL/kg. Intravenous injection of rocuronium stock solution (0.6 mg/kg) was administered 2 minutes later. Pain was evaluated using Ambeshs 4-pointscale. The incidence of rocuronium injection pain was compared among the three groups, and postoperative adverse reactions, such as drowsiness, bradycardia, hypotension, and respiratory depression, were evaluated. RESULTS: The incidence of injection pain among children in group N was significantly lower than that in group C and group L (p<0.05). The incidence of drowsiness in group N was significantly higher than that in the other groups (p<0.05). The incidences of hypotension, bradycardia, and respiratory depression were not significantly different among the three groups (p>0.05). CONCLUSIONS: Intravenous nalbuphine during induction of anesthesia effectively prevented rocuronium-associated injection pain in children. Drowsiness is a complication.
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spelling pubmed-96485912022-12-05 Effect of nalbuphine on rocuronium injection pain Huang, Wenfang Huang, Jinjin Wang, Dongpi Hu, Yaoqin Wang, Jiangmei Lin, Hongfei World J Pediatr Surg Original Research OBJECTIVE: Rocuronium-associated intravenous injection pain occurs frequently in children during induction of anesthesia. The aim of this study was to systematically evaluate the benefits of nalbuphine in patients with rocuronium-associated injection pain. METHODS: Ninety children undergoing tonsillectomy and adenoidectomy in our hospital between October 2019 and September 2020 were randomly divided into the following groups, with 30 patients per group: control group (group C), lidocaine group (group L), and nalbuphine group (group N). Routine 0.1 mg/kg midazolam and 2 mg/kg propofol were injected intravenously. After sedation, children in group C, group L, and group N were administered an intravenous injection of saline, lidocaine (10 mg/mL), or nalbuphine hydrochloride (2 mg/mL), respectively, at a dosage of 0.1 mL/kg. Intravenous injection of rocuronium stock solution (0.6 mg/kg) was administered 2 minutes later. Pain was evaluated using Ambeshs 4-pointscale. The incidence of rocuronium injection pain was compared among the three groups, and postoperative adverse reactions, such as drowsiness, bradycardia, hypotension, and respiratory depression, were evaluated. RESULTS: The incidence of injection pain among children in group N was significantly lower than that in group C and group L (p<0.05). The incidence of drowsiness in group N was significantly higher than that in the other groups (p<0.05). The incidences of hypotension, bradycardia, and respiratory depression were not significantly different among the three groups (p>0.05). CONCLUSIONS: Intravenous nalbuphine during induction of anesthesia effectively prevented rocuronium-associated injection pain in children. Drowsiness is a complication. BMJ Publishing Group 2021-05-27 /pmc/articles/PMC9648591/ /pubmed/36474974 http://dx.doi.org/10.1136/wjps-2020-000249 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Original Research
Huang, Wenfang
Huang, Jinjin
Wang, Dongpi
Hu, Yaoqin
Wang, Jiangmei
Lin, Hongfei
Effect of nalbuphine on rocuronium injection pain
title Effect of nalbuphine on rocuronium injection pain
title_full Effect of nalbuphine on rocuronium injection pain
title_fullStr Effect of nalbuphine on rocuronium injection pain
title_full_unstemmed Effect of nalbuphine on rocuronium injection pain
title_short Effect of nalbuphine on rocuronium injection pain
title_sort effect of nalbuphine on rocuronium injection pain
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648591/
https://www.ncbi.nlm.nih.gov/pubmed/36474974
http://dx.doi.org/10.1136/wjps-2020-000249
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