Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner

Defects in nucleic acid metabolizing enzymes can lead to spontaneous but selective activation of either cGAS/STING or RIG-like receptor (RLR) signaling, causing type I interferon–driven inflammatory diseases. In these pathophysiological conditions, activation of the DNA sensor cGAS and IFN productio...

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Detalles Bibliográficos
Autores principales: Schumann, Tina, Ramon, Santiago Costas, Schubert, Nadja, Mayo, Mohamad Aref, Hega, Melanie, Maser, Katharina Isabell, Ada, Servi-Remzi, Sydow, Lukas, Hajikazemi, Mona, Badstübner, Markus, Müller, Patrick, Ge, Yan, Shakeri, Farhad, Buness, Andreas, Rupf, Benjamin, Lienenklaus, Stefan, Utess, Barbara, Muhandes, Lina, Haase, Michael, Rupp, Luise, Schmitz, Marc, Gramberg, Thomas, Manel, Nicolas, Hartmann, Gunther, Zillinger, Thomas, Kato, Hiroki, Bauer, Stefan, Gerbaulet, Alexander, Paeschke, Katrin, Roers, Axel, Behrendt, Rayk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648672/
https://www.ncbi.nlm.nih.gov/pubmed/36346347
http://dx.doi.org/10.1084/jem.20220829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648672/
https://www.ncbi.nlm.nih.gov/pubmed/36346347
http://dx.doi.org/10.1084/jem.20220829

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