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Mac-2 binding protein glycosylation isomer, the FIB-4 index, and a combination of the two as predictors of non-alcoholic steatohepatitis

Approximately 10% non-alcoholic fatty liver disease (NAFLD) cases progress to non-alcoholic steatohepatitis (NASH). Liver biopsy, the gold standard for diagnosing NASH and associated liver fibrosis, is invasive with a risk of life-threatening complications. Therefore, reliable non-invasive biomarker...

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Autores principales: Kiyoaki, Ito, Sumida, Yoshio, Nakade, Yukiomi, Okumura, Akinori, Nishimura, Sayaka, Ibusuki, Mayu, Kitano, Rena, Sakamoto, Kazumasa, Kimoto, Satoshi, Inoue, Tadahisa, Kobayashi, Yuji, Fukuzawa, Yoshitaka, Yoneda, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648718/
https://www.ncbi.nlm.nih.gov/pubmed/36355761
http://dx.doi.org/10.1371/journal.pone.0277380
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author Kiyoaki, Ito
Sumida, Yoshio
Nakade, Yukiomi
Okumura, Akinori
Nishimura, Sayaka
Ibusuki, Mayu
Kitano, Rena
Sakamoto, Kazumasa
Kimoto, Satoshi
Inoue, Tadahisa
Kobayashi, Yuji
Fukuzawa, Yoshitaka
Yoneda, Masashi
author_facet Kiyoaki, Ito
Sumida, Yoshio
Nakade, Yukiomi
Okumura, Akinori
Nishimura, Sayaka
Ibusuki, Mayu
Kitano, Rena
Sakamoto, Kazumasa
Kimoto, Satoshi
Inoue, Tadahisa
Kobayashi, Yuji
Fukuzawa, Yoshitaka
Yoneda, Masashi
author_sort Kiyoaki, Ito
collection PubMed
description Approximately 10% non-alcoholic fatty liver disease (NAFLD) cases progress to non-alcoholic steatohepatitis (NASH). Liver biopsy, the gold standard for diagnosing NASH and associated liver fibrosis, is invasive with a risk of life-threatening complications. Therefore, reliable non-invasive biomarkers for predicting NASH are required to prevent unnecessary liver biopsies. We evaluated the performance of two non-invasive fibrosis markers, Mac-2 binding protein glycosylation isomer (M2BPGi) and the FIB-4 index for predicting the fibrosis staging, NAFLD activity scoring (NAS) index, and NASH. We also analyzed the correlation between the two markers. The sensitivities, specificities, positive predictive values (PPV), and negative predictive values of the FIB-4 index, M2BPGi, and a combination of both markers for NASH diagnosis were evaluated. The M2BPGi and FIB-4 index showed a good performance in diagnosing NASH, the fibrosis stage, and the NAS index in NAFLD patients. While both markers were well-correlated with each other in most cases, no correlation was found in some patients. Compared with the FIB-4 index or the M2BPGi alone, a combination of the two showed a higher specificity, PPV, and accuracy for NASH diagnosis. The M2BPGi and the FIB-4 index are easily accessible and reliable liver fibrosis markers. Diseases other than liver disease may cause dissociation between the two markers, causing failure to predict NASH. However, the combination of both markers can compensate for their disadvantages. Because the PPV of the combination was relatively high, patients who test positive for both markers should undergo liver biopsy for NASH diagnosis.
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spelling pubmed-96487182022-11-15 Mac-2 binding protein glycosylation isomer, the FIB-4 index, and a combination of the two as predictors of non-alcoholic steatohepatitis Kiyoaki, Ito Sumida, Yoshio Nakade, Yukiomi Okumura, Akinori Nishimura, Sayaka Ibusuki, Mayu Kitano, Rena Sakamoto, Kazumasa Kimoto, Satoshi Inoue, Tadahisa Kobayashi, Yuji Fukuzawa, Yoshitaka Yoneda, Masashi PLoS One Research Article Approximately 10% non-alcoholic fatty liver disease (NAFLD) cases progress to non-alcoholic steatohepatitis (NASH). Liver biopsy, the gold standard for diagnosing NASH and associated liver fibrosis, is invasive with a risk of life-threatening complications. Therefore, reliable non-invasive biomarkers for predicting NASH are required to prevent unnecessary liver biopsies. We evaluated the performance of two non-invasive fibrosis markers, Mac-2 binding protein glycosylation isomer (M2BPGi) and the FIB-4 index for predicting the fibrosis staging, NAFLD activity scoring (NAS) index, and NASH. We also analyzed the correlation between the two markers. The sensitivities, specificities, positive predictive values (PPV), and negative predictive values of the FIB-4 index, M2BPGi, and a combination of both markers for NASH diagnosis were evaluated. The M2BPGi and FIB-4 index showed a good performance in diagnosing NASH, the fibrosis stage, and the NAS index in NAFLD patients. While both markers were well-correlated with each other in most cases, no correlation was found in some patients. Compared with the FIB-4 index or the M2BPGi alone, a combination of the two showed a higher specificity, PPV, and accuracy for NASH diagnosis. The M2BPGi and the FIB-4 index are easily accessible and reliable liver fibrosis markers. Diseases other than liver disease may cause dissociation between the two markers, causing failure to predict NASH. However, the combination of both markers can compensate for their disadvantages. Because the PPV of the combination was relatively high, patients who test positive for both markers should undergo liver biopsy for NASH diagnosis. Public Library of Science 2022-11-10 /pmc/articles/PMC9648718/ /pubmed/36355761 http://dx.doi.org/10.1371/journal.pone.0277380 Text en © 2022 Kiyoaki et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kiyoaki, Ito
Sumida, Yoshio
Nakade, Yukiomi
Okumura, Akinori
Nishimura, Sayaka
Ibusuki, Mayu
Kitano, Rena
Sakamoto, Kazumasa
Kimoto, Satoshi
Inoue, Tadahisa
Kobayashi, Yuji
Fukuzawa, Yoshitaka
Yoneda, Masashi
Mac-2 binding protein glycosylation isomer, the FIB-4 index, and a combination of the two as predictors of non-alcoholic steatohepatitis
title Mac-2 binding protein glycosylation isomer, the FIB-4 index, and a combination of the two as predictors of non-alcoholic steatohepatitis
title_full Mac-2 binding protein glycosylation isomer, the FIB-4 index, and a combination of the two as predictors of non-alcoholic steatohepatitis
title_fullStr Mac-2 binding protein glycosylation isomer, the FIB-4 index, and a combination of the two as predictors of non-alcoholic steatohepatitis
title_full_unstemmed Mac-2 binding protein glycosylation isomer, the FIB-4 index, and a combination of the two as predictors of non-alcoholic steatohepatitis
title_short Mac-2 binding protein glycosylation isomer, the FIB-4 index, and a combination of the two as predictors of non-alcoholic steatohepatitis
title_sort mac-2 binding protein glycosylation isomer, the fib-4 index, and a combination of the two as predictors of non-alcoholic steatohepatitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648718/
https://www.ncbi.nlm.nih.gov/pubmed/36355761
http://dx.doi.org/10.1371/journal.pone.0277380
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