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Ocular-following responses in school-age children

Ocular following eye movements have provided insights into how the visual system of humans and monkeys processes motion. Recently, it has been shown that they also reliably reveal stereoanomalies, and, thus, might have clinical applications. Their translation from research to clinical setting has ho...

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Autores principales: Miladinović, Aleksandar, Quaia, Christian, Ajčević, Miloš, Diplotti, Laura, Cumming, Bruce G., Pensiero, Stefano, Accardo, Agostino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648761/
https://www.ncbi.nlm.nih.gov/pubmed/36355847
http://dx.doi.org/10.1371/journal.pone.0277443
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author Miladinović, Aleksandar
Quaia, Christian
Ajčević, Miloš
Diplotti, Laura
Cumming, Bruce G.
Pensiero, Stefano
Accardo, Agostino
author_facet Miladinović, Aleksandar
Quaia, Christian
Ajčević, Miloš
Diplotti, Laura
Cumming, Bruce G.
Pensiero, Stefano
Accardo, Agostino
author_sort Miladinović, Aleksandar
collection PubMed
description Ocular following eye movements have provided insights into how the visual system of humans and monkeys processes motion. Recently, it has been shown that they also reliably reveal stereoanomalies, and, thus, might have clinical applications. Their translation from research to clinical setting has however been hindered by their small size, which makes them difficult to record, and by a lack of data about their properties in sizable populations. Notably, they have so far only been recorded in adults. We recorded ocular following responses (OFRs)–defined as the change in eye position in the 80–160 ms time window following the motion onset of a large textured stimulus–in 14 school-age children (6 to 13 years old, 9 males and 5 females), under recording conditions that closely mimic a clinical setting. The OFRs were acquired non-invasively by a custom developed high-resolution video-oculography system, described in this study. With the developed system we were able to non-invasively detect OFRs in all children in short recording sessions. Across subjects, we observed a large variability in the magnitude of the movements (by a factor of 4); OFR magnitude was however not correlated with age. A power analysis indicates that even considerably smaller movements could be detected. We conclude that the ocular following system is well developed by age six, and OFRs can be recorded non-invasively in young children in a clinical setting.
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spelling pubmed-96487612022-11-15 Ocular-following responses in school-age children Miladinović, Aleksandar Quaia, Christian Ajčević, Miloš Diplotti, Laura Cumming, Bruce G. Pensiero, Stefano Accardo, Agostino PLoS One Research Article Ocular following eye movements have provided insights into how the visual system of humans and monkeys processes motion. Recently, it has been shown that they also reliably reveal stereoanomalies, and, thus, might have clinical applications. Their translation from research to clinical setting has however been hindered by their small size, which makes them difficult to record, and by a lack of data about their properties in sizable populations. Notably, they have so far only been recorded in adults. We recorded ocular following responses (OFRs)–defined as the change in eye position in the 80–160 ms time window following the motion onset of a large textured stimulus–in 14 school-age children (6 to 13 years old, 9 males and 5 females), under recording conditions that closely mimic a clinical setting. The OFRs were acquired non-invasively by a custom developed high-resolution video-oculography system, described in this study. With the developed system we were able to non-invasively detect OFRs in all children in short recording sessions. Across subjects, we observed a large variability in the magnitude of the movements (by a factor of 4); OFR magnitude was however not correlated with age. A power analysis indicates that even considerably smaller movements could be detected. We conclude that the ocular following system is well developed by age six, and OFRs can be recorded non-invasively in young children in a clinical setting. Public Library of Science 2022-11-10 /pmc/articles/PMC9648761/ /pubmed/36355847 http://dx.doi.org/10.1371/journal.pone.0277443 Text en https://creativecommons.org/publicdomain/zero/1.0/This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Miladinović, Aleksandar
Quaia, Christian
Ajčević, Miloš
Diplotti, Laura
Cumming, Bruce G.
Pensiero, Stefano
Accardo, Agostino
Ocular-following responses in school-age children
title Ocular-following responses in school-age children
title_full Ocular-following responses in school-age children
title_fullStr Ocular-following responses in school-age children
title_full_unstemmed Ocular-following responses in school-age children
title_short Ocular-following responses in school-age children
title_sort ocular-following responses in school-age children
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648761/
https://www.ncbi.nlm.nih.gov/pubmed/36355847
http://dx.doi.org/10.1371/journal.pone.0277443
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