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Prognostic comparison of COVID-19 outpatients and inpatients treated with Remdesivr: A retrospective cohort study
INTRODUCTION: Since the late COVID-19, many countries have faced various surges and peaks within the number of infected. Iran was one of the countries that faced many surges and peaks within these years and faced many inadequacies and shortages of resources and hospital beds. Hence the healthcare sy...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648785/ https://www.ncbi.nlm.nih.gov/pubmed/36356035 http://dx.doi.org/10.1371/journal.pone.0277413 |
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author | Zamani, Shokoofeh Alizadeh, Mohammad Shahrestanaki, Ehsan Mohammadpoor Nami, Sahar Qorbani, Mostafa Aalikhani, Maryam Hassani Gelsefid, Saeed Mohammadian Khonsari, Nami |
author_facet | Zamani, Shokoofeh Alizadeh, Mohammad Shahrestanaki, Ehsan Mohammadpoor Nami, Sahar Qorbani, Mostafa Aalikhani, Maryam Hassani Gelsefid, Saeed Mohammadian Khonsari, Nami |
author_sort | Zamani, Shokoofeh |
collection | PubMed |
description | INTRODUCTION: Since the late COVID-19, many countries have faced various surges and peaks within the number of infected. Iran was one of the countries that faced many surges and peaks within these years and faced many inadequacies and shortages of resources and hospital beds. Hence the healthcare system started using in-hospital medication such as Remdesivir in outpatients to reduce the load of patients admitted to the hospital. This study aimed to evaluate and compare the reported signs, symptoms, and outcomes of COVID-infected hospitalized and out-patients receiving Remdesivir. METHODS: In this retrospective cohort study, 214 patients (121 outpatient and 93 hospitalized) with moderate levels of Covid infection between October 2021 and February 2022 were studied. Both groups were treated with 200mg of Remdesivir, followed by 100 mg daily intravenous injections for five days; signs and symptoms, such as pain, shortness of breath, cough, fever and etc., of patients at the initiation and the end of treatment were recorded. Moreover, the patients’ blood oxygen saturation was assessed two to three times a day, and the mean of the recorded measures was considered as the daily oxygen saturation. The outpatient group had to visit the hospital daily for treatment and assessment. At the treatment’s end, mortality rates, disease signs, and symptoms alleviations were compared between the groups. RESULTS: The outpatient and hospitalized group’s mean age was 40.30 ± 12.25 and 37.70 ± 12.00 years, and 51.2% and 55.9% were males, respectively. There was no statistical difference between baseline and clinical characteristics in the outpatients and hospitalized groups. After adjusting for oxygen saturation at baseline and gender in the multivariable Cox regression analysis, the risk of death did not statistically differ between the hospitalized and outpatient group (hazard ratio: 0.99, 95% confidence interval: 0.39–2.50)) at the end of the study. CONCLUSION: Based on the results of this study, the outcome, signs, and symptoms of inpatient and outpatient Remdesivir treatment groups did not differ significantly. Hence in COVID-19 surges where we have limitations in admitting patients, outpatient Remdesivir treatment for those without any underlying diseases can be a proper management method. |
format | Online Article Text |
id | pubmed-9648785 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-96487852022-11-15 Prognostic comparison of COVID-19 outpatients and inpatients treated with Remdesivr: A retrospective cohort study Zamani, Shokoofeh Alizadeh, Mohammad Shahrestanaki, Ehsan Mohammadpoor Nami, Sahar Qorbani, Mostafa Aalikhani, Maryam Hassani Gelsefid, Saeed Mohammadian Khonsari, Nami PLoS One Research Article INTRODUCTION: Since the late COVID-19, many countries have faced various surges and peaks within the number of infected. Iran was one of the countries that faced many surges and peaks within these years and faced many inadequacies and shortages of resources and hospital beds. Hence the healthcare system started using in-hospital medication such as Remdesivir in outpatients to reduce the load of patients admitted to the hospital. This study aimed to evaluate and compare the reported signs, symptoms, and outcomes of COVID-infected hospitalized and out-patients receiving Remdesivir. METHODS: In this retrospective cohort study, 214 patients (121 outpatient and 93 hospitalized) with moderate levels of Covid infection between October 2021 and February 2022 were studied. Both groups were treated with 200mg of Remdesivir, followed by 100 mg daily intravenous injections for five days; signs and symptoms, such as pain, shortness of breath, cough, fever and etc., of patients at the initiation and the end of treatment were recorded. Moreover, the patients’ blood oxygen saturation was assessed two to three times a day, and the mean of the recorded measures was considered as the daily oxygen saturation. The outpatient group had to visit the hospital daily for treatment and assessment. At the treatment’s end, mortality rates, disease signs, and symptoms alleviations were compared between the groups. RESULTS: The outpatient and hospitalized group’s mean age was 40.30 ± 12.25 and 37.70 ± 12.00 years, and 51.2% and 55.9% were males, respectively. There was no statistical difference between baseline and clinical characteristics in the outpatients and hospitalized groups. After adjusting for oxygen saturation at baseline and gender in the multivariable Cox regression analysis, the risk of death did not statistically differ between the hospitalized and outpatient group (hazard ratio: 0.99, 95% confidence interval: 0.39–2.50)) at the end of the study. CONCLUSION: Based on the results of this study, the outcome, signs, and symptoms of inpatient and outpatient Remdesivir treatment groups did not differ significantly. Hence in COVID-19 surges where we have limitations in admitting patients, outpatient Remdesivir treatment for those without any underlying diseases can be a proper management method. Public Library of Science 2022-11-10 /pmc/articles/PMC9648785/ /pubmed/36356035 http://dx.doi.org/10.1371/journal.pone.0277413 Text en © 2022 Zamani et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Zamani, Shokoofeh Alizadeh, Mohammad Shahrestanaki, Ehsan Mohammadpoor Nami, Sahar Qorbani, Mostafa Aalikhani, Maryam Hassani Gelsefid, Saeed Mohammadian Khonsari, Nami Prognostic comparison of COVID-19 outpatients and inpatients treated with Remdesivr: A retrospective cohort study |
title | Prognostic comparison of COVID-19 outpatients and inpatients treated with Remdesivr: A retrospective cohort study |
title_full | Prognostic comparison of COVID-19 outpatients and inpatients treated with Remdesivr: A retrospective cohort study |
title_fullStr | Prognostic comparison of COVID-19 outpatients and inpatients treated with Remdesivr: A retrospective cohort study |
title_full_unstemmed | Prognostic comparison of COVID-19 outpatients and inpatients treated with Remdesivr: A retrospective cohort study |
title_short | Prognostic comparison of COVID-19 outpatients and inpatients treated with Remdesivr: A retrospective cohort study |
title_sort | prognostic comparison of covid-19 outpatients and inpatients treated with remdesivr: a retrospective cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648785/ https://www.ncbi.nlm.nih.gov/pubmed/36356035 http://dx.doi.org/10.1371/journal.pone.0277413 |
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