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A modular and reusable model of epithelial transport in the proximal convoluted tubule
We review a collection of published renal epithelial transport models, from which we build a consistent and reusable mathematical model able to reproduce many observations and predictions from the literature. The flexible modular model we present here can be adapted to specific configurations of epi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648790/ https://www.ncbi.nlm.nih.gov/pubmed/36355848 http://dx.doi.org/10.1371/journal.pone.0275837 |
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author | Noroozbabaee, Leyla Blanco, Pablo J. Safaei, Soroush Nickerson, David P. |
author_facet | Noroozbabaee, Leyla Blanco, Pablo J. Safaei, Soroush Nickerson, David P. |
author_sort | Noroozbabaee, Leyla |
collection | PubMed |
description | We review a collection of published renal epithelial transport models, from which we build a consistent and reusable mathematical model able to reproduce many observations and predictions from the literature. The flexible modular model we present here can be adapted to specific configurations of epithelial transport, and in this work we focus on transport in the proximal convoluted tubule of the renal nephron. Our mathematical model of the epithelial proximal convoluted tubule describes the cellular and subcellular mechanisms of the transporters, intracellular buffering, solute fluxes, and other processes. We provide free and open access to the Python implementation to ensure our multiscale proximal tubule model is accessible; enabling the reader to explore the model through setting their own simulations, reproducibility tests, and sensitivity analyses. |
format | Online Article Text |
id | pubmed-9648790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-96487902022-11-15 A modular and reusable model of epithelial transport in the proximal convoluted tubule Noroozbabaee, Leyla Blanco, Pablo J. Safaei, Soroush Nickerson, David P. PLoS One Research Article We review a collection of published renal epithelial transport models, from which we build a consistent and reusable mathematical model able to reproduce many observations and predictions from the literature. The flexible modular model we present here can be adapted to specific configurations of epithelial transport, and in this work we focus on transport in the proximal convoluted tubule of the renal nephron. Our mathematical model of the epithelial proximal convoluted tubule describes the cellular and subcellular mechanisms of the transporters, intracellular buffering, solute fluxes, and other processes. We provide free and open access to the Python implementation to ensure our multiscale proximal tubule model is accessible; enabling the reader to explore the model through setting their own simulations, reproducibility tests, and sensitivity analyses. Public Library of Science 2022-11-10 /pmc/articles/PMC9648790/ /pubmed/36355848 http://dx.doi.org/10.1371/journal.pone.0275837 Text en © 2022 Noroozbabaee et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Noroozbabaee, Leyla Blanco, Pablo J. Safaei, Soroush Nickerson, David P. A modular and reusable model of epithelial transport in the proximal convoluted tubule |
title | A modular and reusable model of epithelial transport in the proximal convoluted tubule |
title_full | A modular and reusable model of epithelial transport in the proximal convoluted tubule |
title_fullStr | A modular and reusable model of epithelial transport in the proximal convoluted tubule |
title_full_unstemmed | A modular and reusable model of epithelial transport in the proximal convoluted tubule |
title_short | A modular and reusable model of epithelial transport in the proximal convoluted tubule |
title_sort | modular and reusable model of epithelial transport in the proximal convoluted tubule |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648790/ https://www.ncbi.nlm.nih.gov/pubmed/36355848 http://dx.doi.org/10.1371/journal.pone.0275837 |
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