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Gabrb2 knock-out mice exhibit double-directed PMDD-like symptoms: GABAAR subunits, neurotransmitter metabolism disruption, and allopregnanolone binding

Background: Premenstrual dysphoric disorder (PMDD) is a severe mood disorder with pathological changes rooted in GABRB2 copy number variation. Here, we aimed to elucidate the gene dose effect and allopregnanolone binding mechanism of Gabrb2 on possible PMDD-like and comorbid phenotypes in knockout m...

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Detalles Bibliográficos
Autores principales:	Gao, Mingzhou, Zhang, Hao, Sun, Ya, Gao, Zhan, Sun, Chunyan, Wei, Fengqin, Gao, Dongmei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648806/ https://www.ncbi.nlm.nih.gov/pubmed/36287173 http://dx.doi.org/10.18632/aging.204351

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