AR12 increases BAG3 expression which is essential for Tau and APP degradation via LC3-associated phagocytosis and macroautophagy

We defined the mechanisms by which the chaperone ATPase inhibitor AR12 and the multi-kinase inhibitor neratinib interacted to reduce expression of Tau and amyloid-precursor protein (APP) in microglia and neuronal cells. AR12 and neratinib interacted to increase the phosphorylation of eIF2A S51 and t...

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Detalles Bibliográficos
Autores principales: Dent, Paul, Booth, Laurence, Roberts, Jane L., Poklepovic, Andrew, Martinez, Jennifer, Cridebring, Derek, Reiman, Eric M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648812/
https://www.ncbi.nlm.nih.gov/pubmed/36227739
http://dx.doi.org/10.18632/aging.204337

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