Acidic environments trigger intracellular H(+)-sensing FAK proteins to re-balance sarcolemmal acid–base transporters and auto-regulate cardiomyocyte pH

AIMS: In cardiomyocytes, acute disturbances to intracellular pH (pHi) are promptly corrected by a system of finely tuned sarcolemmal acid–base transporters. However, these fluxes become thermodynamically re-balanced in acidic environments, which inadvertently causes their set-point pHi to fall outsi...

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Detalles Bibliográficos
Autores principales: Wilson, Abigail D, Richards, Mark A, Curtis, M Kate, Gunadasa-Rohling, Mala, Monterisi, Stefania, Loonat, Aminah A, Miller, Jack J, Ball, Vicky, Lewis, Andrew, Tyler, Damian J, Moshnikova, Anna, Andreev, Oleg A, Reshetnyak, Yana K, Carr, Carolyn, Swietach, Pawel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648823/
https://www.ncbi.nlm.nih.gov/pubmed/34897412
http://dx.doi.org/10.1093/cvr/cvab364

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