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Translational buffering by ribosome stalling in upstream open reading frames

Upstream open reading frames (uORFs) are present in over half of all human mRNAs. uORFs can potently regulate the translation of downstream open reading frames through several mechanisms: siphoning away scanning ribosomes, regulating re-initiation, and allowing interactions between scanning and elon...

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Detalles Bibliográficos
Autores principales:	Bottorff, Ty A., Park, Heungwon, Geballe, Adam P., Subramaniam, Arvind Rasi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648851/ https://www.ncbi.nlm.nih.gov/pubmed/36315596 http://dx.doi.org/10.1371/journal.pgen.1010460

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