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Mitochondrial DNA: Consensuses and Controversies
In the course of its short history, mitochondrial DNA (mtDNA) has made a long journey from obscurity to the forefront of research on major biological processes. mtDNA alterations have been found in all major disease groups, and their significance remains the subject of intense research. Despite rema...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648901/ https://www.ncbi.nlm.nih.gov/pubmed/36381197 http://dx.doi.org/10.3390/dna2020010 |
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author | Shokolenko, Inna Alexeyev, Mikhail |
author_facet | Shokolenko, Inna Alexeyev, Mikhail |
author_sort | Shokolenko, Inna |
collection | PubMed |
description | In the course of its short history, mitochondrial DNA (mtDNA) has made a long journey from obscurity to the forefront of research on major biological processes. mtDNA alterations have been found in all major disease groups, and their significance remains the subject of intense research. Despite remarkable progress, our understanding of the major aspects of mtDNA biology, such as its replication, damage, repair, transcription, maintenance, etc., is frustratingly limited. The path to better understanding mtDNA and its role in cells, however, remains torturous and not without errors, which sometimes leave a long trail of controversy behind them. This review aims to provide a brief summary of our current knowledge of mtDNA and highlight some of the controversies that require attention from the mitochondrial research community. |
format | Online Article Text |
id | pubmed-9648901 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
record_format | MEDLINE/PubMed |
spelling | pubmed-96489012022-11-14 Mitochondrial DNA: Consensuses and Controversies Shokolenko, Inna Alexeyev, Mikhail DNA (Basel) Article In the course of its short history, mitochondrial DNA (mtDNA) has made a long journey from obscurity to the forefront of research on major biological processes. mtDNA alterations have been found in all major disease groups, and their significance remains the subject of intense research. Despite remarkable progress, our understanding of the major aspects of mtDNA biology, such as its replication, damage, repair, transcription, maintenance, etc., is frustratingly limited. The path to better understanding mtDNA and its role in cells, however, remains torturous and not without errors, which sometimes leave a long trail of controversy behind them. This review aims to provide a brief summary of our current knowledge of mtDNA and highlight some of the controversies that require attention from the mitochondrial research community. 2022-06 2022-06-10 /pmc/articles/PMC9648901/ /pubmed/36381197 http://dx.doi.org/10.3390/dna2020010 Text en https://creativecommons.org/licenses/by/4.0/This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Shokolenko, Inna Alexeyev, Mikhail Mitochondrial DNA: Consensuses and Controversies |
title | Mitochondrial DNA: Consensuses and Controversies |
title_full | Mitochondrial DNA: Consensuses and Controversies |
title_fullStr | Mitochondrial DNA: Consensuses and Controversies |
title_full_unstemmed | Mitochondrial DNA: Consensuses and Controversies |
title_short | Mitochondrial DNA: Consensuses and Controversies |
title_sort | mitochondrial dna: consensuses and controversies |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648901/ https://www.ncbi.nlm.nih.gov/pubmed/36381197 http://dx.doi.org/10.3390/dna2020010 |
work_keys_str_mv | AT shokolenkoinna mitochondrialdnaconsensusesandcontroversies AT alexeyevmikhail mitochondrialdnaconsensusesandcontroversies |