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Mitochondrial DNA: Consensuses and Controversies

In the course of its short history, mitochondrial DNA (mtDNA) has made a long journey from obscurity to the forefront of research on major biological processes. mtDNA alterations have been found in all major disease groups, and their significance remains the subject of intense research. Despite rema...

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Autores principales: Shokolenko, Inna, Alexeyev, Mikhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648901/
https://www.ncbi.nlm.nih.gov/pubmed/36381197
http://dx.doi.org/10.3390/dna2020010
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author Shokolenko, Inna
Alexeyev, Mikhail
author_facet Shokolenko, Inna
Alexeyev, Mikhail
author_sort Shokolenko, Inna
collection PubMed
description In the course of its short history, mitochondrial DNA (mtDNA) has made a long journey from obscurity to the forefront of research on major biological processes. mtDNA alterations have been found in all major disease groups, and their significance remains the subject of intense research. Despite remarkable progress, our understanding of the major aspects of mtDNA biology, such as its replication, damage, repair, transcription, maintenance, etc., is frustratingly limited. The path to better understanding mtDNA and its role in cells, however, remains torturous and not without errors, which sometimes leave a long trail of controversy behind them. This review aims to provide a brief summary of our current knowledge of mtDNA and highlight some of the controversies that require attention from the mitochondrial research community.
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spelling pubmed-96489012022-11-14 Mitochondrial DNA: Consensuses and Controversies Shokolenko, Inna Alexeyev, Mikhail DNA (Basel) Article In the course of its short history, mitochondrial DNA (mtDNA) has made a long journey from obscurity to the forefront of research on major biological processes. mtDNA alterations have been found in all major disease groups, and their significance remains the subject of intense research. Despite remarkable progress, our understanding of the major aspects of mtDNA biology, such as its replication, damage, repair, transcription, maintenance, etc., is frustratingly limited. The path to better understanding mtDNA and its role in cells, however, remains torturous and not without errors, which sometimes leave a long trail of controversy behind them. This review aims to provide a brief summary of our current knowledge of mtDNA and highlight some of the controversies that require attention from the mitochondrial research community. 2022-06 2022-06-10 /pmc/articles/PMC9648901/ /pubmed/36381197 http://dx.doi.org/10.3390/dna2020010 Text en https://creativecommons.org/licenses/by/4.0/This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shokolenko, Inna
Alexeyev, Mikhail
Mitochondrial DNA: Consensuses and Controversies
title Mitochondrial DNA: Consensuses and Controversies
title_full Mitochondrial DNA: Consensuses and Controversies
title_fullStr Mitochondrial DNA: Consensuses and Controversies
title_full_unstemmed Mitochondrial DNA: Consensuses and Controversies
title_short Mitochondrial DNA: Consensuses and Controversies
title_sort mitochondrial dna: consensuses and controversies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648901/
https://www.ncbi.nlm.nih.gov/pubmed/36381197
http://dx.doi.org/10.3390/dna2020010
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