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Quality of life, disability, and clinical variables in amyotrophic lateral sclerosis
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a motor neuron disease that results in a progressive increase in dysfunctions, limitations and restrictions over time, which can impact on quality of life (QoL). Therefore, expanding knowledge on QoL and possible factors associated with ALS can enab...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Academia Brasileira de Neurologia -ABNEURO
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648935/ https://www.ncbi.nlm.nih.gov/pubmed/34932653 http://dx.doi.org/10.1590/0004-282X-ANP-2021-0201 |
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author | Alencar, Mariana Asmar da Silva, Izaura Monique Moura Hilário, Stéfanie Marcelle Rangel, Marcela Ferreira de Andrade Abdo, Juliana Silva de Araújo, Caroline Martins de Souza, Leonardo Cruz |
author_facet | Alencar, Mariana Asmar da Silva, Izaura Monique Moura Hilário, Stéfanie Marcelle Rangel, Marcela Ferreira de Andrade Abdo, Juliana Silva de Araújo, Caroline Martins de Souza, Leonardo Cruz |
author_sort | Alencar, Mariana Asmar |
collection | PubMed |
description | BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a motor neuron disease that results in a progressive increase in dysfunctions, limitations and restrictions over time, which can impact on quality of life (QoL). Therefore, expanding knowledge on QoL and possible factors associated with ALS can enable the development of actions to ensure greater wellbeing for the population. OBJECTIVE: To investigate QoL in ALS and determine associations with demographic, functional and clinical aspects. METHODS: Forty-five individuals with ALS (56.4±11.1 years) participated in the study. Demographic, clinical and functional aspects were investigated. Functioning and QoL were assessed using disease-specific tools (ALS Functional Ranting Scale-Revised/ALSFRS-R and ALS Assessment Questionnaire/ALSAQ-40). Fatigue was assessed using the Fatigue Severity Scale. Descriptive, correlation and stepwise multiple linear regression analyses were performed with the aid of the SPSS. RESULTS: The mean ALSAQ-40 score was 279.0±118.3. QoL was significantly worse among women (p=0.001) and poor QoL was associated with the inability to walk (p=0.014), pain (p=0.021) and disease severity (p≤0.002). QoL was strongly correlated with the ALSFRS-R score (r=-0.82). Moderate to weak correlations were found for mobility [turning in bed (r=-0.62), locomotion (r=-0.33) and sit to stand (r=-0.40)], strength (r=-0.49), fatigue (r=0.35) and pain (r=-0.32) (p<0.03). The regression analysis revealed that the ALSFRS-R score (β=-0.76; p=0.00) and fatigue (β=0.20; p=0.04) were predictors of QoL. CONCLUSIONS: QoL was worse in women, older people, severe stages of ALS, patients with impaired mobility, those with a poorer physical performance and those who reported pain. Functional status and fatigue are predictors of QoL in ALS. |
format | Online Article Text |
id | pubmed-9648935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Academia Brasileira de Neurologia -ABNEURO |
record_format | MEDLINE/PubMed |
spelling | pubmed-96489352022-12-08 Quality of life, disability, and clinical variables in amyotrophic lateral sclerosis Alencar, Mariana Asmar da Silva, Izaura Monique Moura Hilário, Stéfanie Marcelle Rangel, Marcela Ferreira de Andrade Abdo, Juliana Silva de Araújo, Caroline Martins de Souza, Leonardo Cruz Arq Neuropsiquiatr Article BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a motor neuron disease that results in a progressive increase in dysfunctions, limitations and restrictions over time, which can impact on quality of life (QoL). Therefore, expanding knowledge on QoL and possible factors associated with ALS can enable the development of actions to ensure greater wellbeing for the population. OBJECTIVE: To investigate QoL in ALS and determine associations with demographic, functional and clinical aspects. METHODS: Forty-five individuals with ALS (56.4±11.1 years) participated in the study. Demographic, clinical and functional aspects were investigated. Functioning and QoL were assessed using disease-specific tools (ALS Functional Ranting Scale-Revised/ALSFRS-R and ALS Assessment Questionnaire/ALSAQ-40). Fatigue was assessed using the Fatigue Severity Scale. Descriptive, correlation and stepwise multiple linear regression analyses were performed with the aid of the SPSS. RESULTS: The mean ALSAQ-40 score was 279.0±118.3. QoL was significantly worse among women (p=0.001) and poor QoL was associated with the inability to walk (p=0.014), pain (p=0.021) and disease severity (p≤0.002). QoL was strongly correlated with the ALSFRS-R score (r=-0.82). Moderate to weak correlations were found for mobility [turning in bed (r=-0.62), locomotion (r=-0.33) and sit to stand (r=-0.40)], strength (r=-0.49), fatigue (r=0.35) and pain (r=-0.32) (p<0.03). The regression analysis revealed that the ALSFRS-R score (β=-0.76; p=0.00) and fatigue (β=0.20; p=0.04) were predictors of QoL. CONCLUSIONS: QoL was worse in women, older people, severe stages of ALS, patients with impaired mobility, those with a poorer physical performance and those who reported pain. Functional status and fatigue are predictors of QoL in ALS. Academia Brasileira de Neurologia -ABNEURO 2021-12-31 /pmc/articles/PMC9648935/ /pubmed/34932653 http://dx.doi.org/10.1590/0004-282X-ANP-2021-0201 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Article Alencar, Mariana Asmar da Silva, Izaura Monique Moura Hilário, Stéfanie Marcelle Rangel, Marcela Ferreira de Andrade Abdo, Juliana Silva de Araújo, Caroline Martins de Souza, Leonardo Cruz Quality of life, disability, and clinical variables in amyotrophic lateral sclerosis |
title | Quality of life, disability, and clinical variables in amyotrophic lateral sclerosis |
title_full | Quality of life, disability, and clinical variables in amyotrophic lateral sclerosis |
title_fullStr | Quality of life, disability, and clinical variables in amyotrophic lateral sclerosis |
title_full_unstemmed | Quality of life, disability, and clinical variables in amyotrophic lateral sclerosis |
title_short | Quality of life, disability, and clinical variables in amyotrophic lateral sclerosis |
title_sort | quality of life, disability, and clinical variables in amyotrophic lateral sclerosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648935/ https://www.ncbi.nlm.nih.gov/pubmed/34932653 http://dx.doi.org/10.1590/0004-282X-ANP-2021-0201 |
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