Systemic Mastocytosis in a Patient with BCR-ABL1-Positive Chronic Myeloid Leukemia in the Remission Phase

Systemic mastocytosis (SM) comprises a group of rare disorders resulting from tissue infiltration by pathological mast cells. In a percentage ranging from 5 to 40% in various patient series, SM appears to be associated with an accompanying hematologic neoplasm (SM-AHN). The coexistence of SM with ch...

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Autores principales: Fokoloros, Christos, Foukas, Periklis, Georgakopoulos, Nikolaos, Tsakiraki, Zoi, Bouchla, Anthi, Pappa, Vasilliki, Katoulis, Alexandros, Makris, Michael, Papageorgiou, Sotirios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649302/
https://www.ncbi.nlm.nih.gov/pubmed/36389397
http://dx.doi.org/10.1155/2022/7251658
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author Fokoloros, Christos
Foukas, Periklis
Georgakopoulos, Nikolaos
Tsakiraki, Zoi
Bouchla, Anthi
Pappa, Vasilliki
Katoulis, Alexandros
Makris, Michael
Papageorgiou, Sotirios
author_facet Fokoloros, Christos
Foukas, Periklis
Georgakopoulos, Nikolaos
Tsakiraki, Zoi
Bouchla, Anthi
Pappa, Vasilliki
Katoulis, Alexandros
Makris, Michael
Papageorgiou, Sotirios
author_sort Fokoloros, Christos
collection PubMed
description Systemic mastocytosis (SM) comprises a group of rare disorders resulting from tissue infiltration by pathological mast cells. In a percentage ranging from 5 to 40% in various patient series, SM appears to be associated with an accompanying hematologic neoplasm (SM-AHN). The coexistence of SM with chronic myelogenous leukemia (CML) is extremely rare with only 3 cases in the literature. The natural course of CML has changed dramatically over the past 2 decades with the use of tyrosine kinase inhibitors (TKIs). We report a case of diagnosing SM in a patient in complete molecular remission of CML after stopping TKI treatment.
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spelling pubmed-96493022022-11-15 Systemic Mastocytosis in a Patient with BCR-ABL1-Positive Chronic Myeloid Leukemia in the Remission Phase Fokoloros, Christos Foukas, Periklis Georgakopoulos, Nikolaos Tsakiraki, Zoi Bouchla, Anthi Pappa, Vasilliki Katoulis, Alexandros Makris, Michael Papageorgiou, Sotirios Case Rep Hematol Case Report Systemic mastocytosis (SM) comprises a group of rare disorders resulting from tissue infiltration by pathological mast cells. In a percentage ranging from 5 to 40% in various patient series, SM appears to be associated with an accompanying hematologic neoplasm (SM-AHN). The coexistence of SM with chronic myelogenous leukemia (CML) is extremely rare with only 3 cases in the literature. The natural course of CML has changed dramatically over the past 2 decades with the use of tyrosine kinase inhibitors (TKIs). We report a case of diagnosing SM in a patient in complete molecular remission of CML after stopping TKI treatment. Hindawi 2022-11-03 /pmc/articles/PMC9649302/ /pubmed/36389397 http://dx.doi.org/10.1155/2022/7251658 Text en Copyright © 2022 Christos Fokoloros et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Fokoloros, Christos
Foukas, Periklis
Georgakopoulos, Nikolaos
Tsakiraki, Zoi
Bouchla, Anthi
Pappa, Vasilliki
Katoulis, Alexandros
Makris, Michael
Papageorgiou, Sotirios
Systemic Mastocytosis in a Patient with BCR-ABL1-Positive Chronic Myeloid Leukemia in the Remission Phase
title Systemic Mastocytosis in a Patient with BCR-ABL1-Positive Chronic Myeloid Leukemia in the Remission Phase
title_full Systemic Mastocytosis in a Patient with BCR-ABL1-Positive Chronic Myeloid Leukemia in the Remission Phase
title_fullStr Systemic Mastocytosis in a Patient with BCR-ABL1-Positive Chronic Myeloid Leukemia in the Remission Phase
title_full_unstemmed Systemic Mastocytosis in a Patient with BCR-ABL1-Positive Chronic Myeloid Leukemia in the Remission Phase
title_short Systemic Mastocytosis in a Patient with BCR-ABL1-Positive Chronic Myeloid Leukemia in the Remission Phase
title_sort systemic mastocytosis in a patient with bcr-abl1-positive chronic myeloid leukemia in the remission phase
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649302/
https://www.ncbi.nlm.nih.gov/pubmed/36389397
http://dx.doi.org/10.1155/2022/7251658
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