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Preclinical study for the ameliorating effect of l-ascorbic acid for the oxidative stress of chronic administration of organic nitrates on myocardial tissue in high sucrose/fat rat model

BACKGROUND: The therapeutic activity of Glyceryl trinitrate (GTN) is mainly regulated by liberating nitric oxide (NO) and reactive nitrogen species (RNS). During this biotransformation, oxidative stress and lipid peroxidation inside the red blood cells (RBCs) occur. Hemoglobin tightly binds to NO fo...

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Detalles Bibliográficos
Autores principales:	Hamdan, Ahmed Mohsen Elsaid, Mohammedsaleh, Zuhair M., Aboelnour, Aalaa, Elkannishy, Sherif M.H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649357/ https://www.ncbi.nlm.nih.gov/pubmed/36387332 http://dx.doi.org/10.1016/j.jsps.2022.07.001

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