A novel oral medicated jelly for enhancement of etilefrine hydrochloride bioavailability: In vitro characterization and pharmacokinetic evaluation in healthy human volunteers

Etilefrine hydrochloride (ET) is a water-soluble drug that is used to treat hypotension, but it has a bitter taste and low bioavailability due to undergoing the first-pass effect. Thus, this study aimed to develop and evaluate oral medicated jelly (OMJ) containing ET that could offer an easily taken...

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Detalles Bibliográficos
Autores principales: Hassen Elshafeey, Ahmed, Moataz El-Dahmy, Rania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649358/
https://www.ncbi.nlm.nih.gov/pubmed/36387345
http://dx.doi.org/10.1016/j.jsps.2022.07.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649358/
https://www.ncbi.nlm.nih.gov/pubmed/36387345
http://dx.doi.org/10.1016/j.jsps.2022.07.004

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