DNA sequence and chromatin modifiers cooperate to confer epigenetic bistability at imprinting control regions

Genomic imprinting is regulated by parental-specific DNA methylation of imprinting control regions (ICRs). Despite an identical DNA sequence, ICRs can exist in two distinct epigenetic states that are memorized throughout unlimited cell divisions and reset during germline formation. Here, we systemat...

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Detalles Bibliográficos
Autores principales: Butz, Stefan, Schmolka, Nina, Karemaker, Ino D., Villaseñor, Rodrigo, Schwarz, Isabel, Domcke, Silvia, Uijttewaal, Esther C. H., Jude, Julian, Lienert, Florian, Krebs, Arnaud R., de Wagenaar, Nathalie P., Bao, Xue, Zuber, Johannes, Elling, Ulrich, Schübeler, Dirk, Baubec, Tuncay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649441/
https://www.ncbi.nlm.nih.gov/pubmed/36333500
http://dx.doi.org/10.1038/s41588-022-01210-z

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