Molecular docking analysis of FDA approved drugs with the glycoprotein from Junin and Machupo viruses

Arenaviruses, Junin and Machupo are pathogenic viruses in regions of South America including Argentina and Bolivia causing haemorrhagic fever among humans. They have been transmitted to humans through mouse causing chronic illness with high mortality. Therefore, it is of interest to acquittance the...

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Autores principales: Malhotra, Himani, Kumar, Arvind, Afaq, Yasir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649494/
https://www.ncbi.nlm.nih.gov/pubmed/36420432
http://dx.doi.org/10.6026/97320630018119
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author Malhotra, Himani
Kumar, Arvind
Afaq, Yasir
author_facet Malhotra, Himani
Kumar, Arvind
Afaq, Yasir
author_sort Malhotra, Himani
collection PubMed
description Arenaviruses, Junin and Machupo are pathogenic viruses in regions of South America including Argentina and Bolivia causing haemorrhagic fever among humans. They have been transmitted to humans through mouse causing chronic illness with high mortality. Therefore, it is of interest to acquittance the molecular docking analysis data of FDA approved drugs with the glycoprotein from Junin and Machupo viruses for consideration in drug discovery. Thus, we report the optimal binding features of MK-3207 and Dihydro ergotamine with the protein target for further validation and consideration.
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spelling pubmed-96494942022-11-22 Molecular docking analysis of FDA approved drugs with the glycoprotein from Junin and Machupo viruses Malhotra, Himani Kumar, Arvind Afaq, Yasir Bioinformation Research Article Arenaviruses, Junin and Machupo are pathogenic viruses in regions of South America including Argentina and Bolivia causing haemorrhagic fever among humans. They have been transmitted to humans through mouse causing chronic illness with high mortality. Therefore, it is of interest to acquittance the molecular docking analysis data of FDA approved drugs with the glycoprotein from Junin and Machupo viruses for consideration in drug discovery. Thus, we report the optimal binding features of MK-3207 and Dihydro ergotamine with the protein target for further validation and consideration. Biomedical Informatics 2022-02-28 /pmc/articles/PMC9649494/ /pubmed/36420432 http://dx.doi.org/10.6026/97320630018119 Text en © 2022 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research Article
Malhotra, Himani
Kumar, Arvind
Afaq, Yasir
Molecular docking analysis of FDA approved drugs with the glycoprotein from Junin and Machupo viruses
title Molecular docking analysis of FDA approved drugs with the glycoprotein from Junin and Machupo viruses
title_full Molecular docking analysis of FDA approved drugs with the glycoprotein from Junin and Machupo viruses
title_fullStr Molecular docking analysis of FDA approved drugs with the glycoprotein from Junin and Machupo viruses
title_full_unstemmed Molecular docking analysis of FDA approved drugs with the glycoprotein from Junin and Machupo viruses
title_short Molecular docking analysis of FDA approved drugs with the glycoprotein from Junin and Machupo viruses
title_sort molecular docking analysis of fda approved drugs with the glycoprotein from junin and machupo viruses
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649494/
https://www.ncbi.nlm.nih.gov/pubmed/36420432
http://dx.doi.org/10.6026/97320630018119
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AT afaqyasir moleculardockinganalysisoffdaapproveddrugswiththeglycoproteinfromjuninandmachupoviruses

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