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Relationship between lipids and sleep apnea: Mendelian randomization analysis

BACKGROUND: Lipids increase the risk of sleep apnea; however, the causality between them is still inconclusive. AIM: To explore the causal relationship between serum lipids and sleep apnea using two-sample Mendelian randomization (MR) analysis. METHODS: Single nucleotide polymorphism (SNP) data rela...

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Detalles Bibliográficos
Autores principales: Zhang, Lian-Peng, Zhang, Xiao-Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649573/
https://www.ncbi.nlm.nih.gov/pubmed/36387818
http://dx.doi.org/10.12998/wjcc.v10.i31.11403
Descripción
Sumario:BACKGROUND: Lipids increase the risk of sleep apnea; however, the causality between them is still inconclusive. AIM: To explore the causal relationship between serum lipids and sleep apnea using two-sample Mendelian randomization (MR) analysis. METHODS: Single nucleotide polymorphism (SNP) data related to serum lipids were obtained from the Global Lipids Genetics Consortium study, which included 188578 individuals of European ancestry. Additionally, sleep apnea-related SNP data were collected from the United Kingdom Biobank study, which comprised 463005 individuals of European ancestry. Two-sample MR analysis was performed to assess the causality between serum lipids and sleep apnea based on the above public data. RESULTS: Genetically predicted low-density lipoprotein (odds ratio [OR] = 0.99, 95% confidence interval [CI] = 0.99 to 1.00; P = 0.58), high-density lipoprotein (OR = 0.99, 95%CI = 0.99 to 1.00; P = 0.91), triglyceride (OR = 1.00, 95%CI = 0.99 to 1.00; P = 0.92), and total cholesterol (OR = 0.99, 95%CI = 0.99 to 1.00; P = 0.33) were causally unrelated to sleep apnea. CONCLUSION: Our MR analysis suggests that genetically predicted serum lipids are not risk factors of sleep apnea.