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Ca(2+) entry units in a superfast fish muscle
Over the past two decades, mounting evidence has demonstrated that a mechanism known as store-operated Ca(2+) entry (SOCE) plays a crucial role in sustaining skeletal muscle contractility by facilitating Ca(2+) influx from the extracellular space during sarcoplasmic reticulum (SR) Ca(2+) depletion....
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649577/ https://www.ncbi.nlm.nih.gov/pubmed/36388096 http://dx.doi.org/10.3389/fphys.2022.1036594 |
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author | Kittelberger, J. Matthew Franzini-Armstrong, Clara Boncompagni, Simona |
author_facet | Kittelberger, J. Matthew Franzini-Armstrong, Clara Boncompagni, Simona |
author_sort | Kittelberger, J. Matthew |
collection | PubMed |
description | Over the past two decades, mounting evidence has demonstrated that a mechanism known as store-operated Ca(2+) entry (SOCE) plays a crucial role in sustaining skeletal muscle contractility by facilitating Ca(2+) influx from the extracellular space during sarcoplasmic reticulum (SR) Ca(2+) depletion. We recently demonstrated that, in exercised fast-twitch muscle from mice, the incidence of Ca(2+) entry units (CEUs), newly described intracellular junctions between dead-end longitudinal transverse tubular (T-tubule) extensions and stacks of sarcoplasmic reticulum (SR) flat cisternae, strictly correlate with both the capability of fibers to maintain contractions during fatigue and enhanced Ca(2+) influx via SOCE. Here, we tested the broader relevance of this result across vertebrates by searching for the presence of CEUs in the vocal muscles of a teleost fish adapted for extended, high-frequency activity. Specifically, we examined active vs. inactive superfast sonic muscles of plainfin midshipman (Porichthys notatus). Interestingly, muscles from actively humming territorial males had a much higher incidence of CEU SR stacks relative to territorial males that were not actively vocalizing, strengthening the concept that assembly of these structures is dynamic and use-dependent, as recently described in exercised muscles from mice. Our results support the hypothesis that CEUs represent a conserved mechanism, across vertebrates, for enabling high levels of repetitive muscle activity, and also provide new insights into the adaptive mechanisms underlying the unique properties of superfast midshipman sonic muscles. |
format | Online Article Text |
id | pubmed-9649577 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96495772022-11-15 Ca(2+) entry units in a superfast fish muscle Kittelberger, J. Matthew Franzini-Armstrong, Clara Boncompagni, Simona Front Physiol Physiology Over the past two decades, mounting evidence has demonstrated that a mechanism known as store-operated Ca(2+) entry (SOCE) plays a crucial role in sustaining skeletal muscle contractility by facilitating Ca(2+) influx from the extracellular space during sarcoplasmic reticulum (SR) Ca(2+) depletion. We recently demonstrated that, in exercised fast-twitch muscle from mice, the incidence of Ca(2+) entry units (CEUs), newly described intracellular junctions between dead-end longitudinal transverse tubular (T-tubule) extensions and stacks of sarcoplasmic reticulum (SR) flat cisternae, strictly correlate with both the capability of fibers to maintain contractions during fatigue and enhanced Ca(2+) influx via SOCE. Here, we tested the broader relevance of this result across vertebrates by searching for the presence of CEUs in the vocal muscles of a teleost fish adapted for extended, high-frequency activity. Specifically, we examined active vs. inactive superfast sonic muscles of plainfin midshipman (Porichthys notatus). Interestingly, muscles from actively humming territorial males had a much higher incidence of CEU SR stacks relative to territorial males that were not actively vocalizing, strengthening the concept that assembly of these structures is dynamic and use-dependent, as recently described in exercised muscles from mice. Our results support the hypothesis that CEUs represent a conserved mechanism, across vertebrates, for enabling high levels of repetitive muscle activity, and also provide new insights into the adaptive mechanisms underlying the unique properties of superfast midshipman sonic muscles. Frontiers Media S.A. 2022-10-28 /pmc/articles/PMC9649577/ /pubmed/36388096 http://dx.doi.org/10.3389/fphys.2022.1036594 Text en Copyright © 2022 Kittelberger, Franzini-Armstrong and Boncompagni. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Kittelberger, J. Matthew Franzini-Armstrong, Clara Boncompagni, Simona Ca(2+) entry units in a superfast fish muscle |
title | Ca(2+) entry units in a superfast fish muscle |
title_full | Ca(2+) entry units in a superfast fish muscle |
title_fullStr | Ca(2+) entry units in a superfast fish muscle |
title_full_unstemmed | Ca(2+) entry units in a superfast fish muscle |
title_short | Ca(2+) entry units in a superfast fish muscle |
title_sort | ca(2+) entry units in a superfast fish muscle |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649577/ https://www.ncbi.nlm.nih.gov/pubmed/36388096 http://dx.doi.org/10.3389/fphys.2022.1036594 |
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