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A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan
Recent advances in cell reprogramming showed that OSKM induction is able to improve cell physiology in vitro and in vivo. Here, we show that a single short reprogramming induction is sufficient to prevent musculoskeletal functions deterioration of mice, when applied in early life. In addition, in ol...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649606/ https://www.ncbi.nlm.nih.gov/pubmed/36251933 http://dx.doi.org/10.1111/acel.13714 |
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| author | Alle, Quentin Le Borgne, Enora Bensadoun, Paul Lemey, Camille Béchir, Nelly Gabanou, Mélissa Estermann, Fanny Bertrand‐Gaday, Christelle Pessemesse, Laurence Toupet, Karine Desprat, Romain Vialaret, Jérôme Hirtz, Christophe Noël, Danièle Jorgensen, Christian Casas, François Milhavet, Ollivier Lemaitre, Jean‐Marc |
| author_facet | Alle, Quentin Le Borgne, Enora Bensadoun, Paul Lemey, Camille Béchir, Nelly Gabanou, Mélissa Estermann, Fanny Bertrand‐Gaday, Christelle Pessemesse, Laurence Toupet, Karine Desprat, Romain Vialaret, Jérôme Hirtz, Christophe Noël, Danièle Jorgensen, Christian Casas, François Milhavet, Ollivier Lemaitre, Jean‐Marc |
| author_sort | Alle, Quentin |
| collection | PubMed |
| description | Recent advances in cell reprogramming showed that OSKM induction is able to improve cell physiology in vitro and in vivo. Here, we show that a single short reprogramming induction is sufficient to prevent musculoskeletal functions deterioration of mice, when applied in early life. In addition, in old age, treated mice have improved tissue structures in kidney, spleen, skin, and lung, with an increased lifespan of 15% associated with organ‐specific differential age‐related DNA methylation signatures rejuvenated by the treatment. Altogether, our results indicate that a single short reprogramming early in life might initiate and propagate an epigenetically related mechanism to promote a healthy lifespan. |
| format | Online Article Text |
| id | pubmed-9649606 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-96496062022-11-14 A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan Alle, Quentin Le Borgne, Enora Bensadoun, Paul Lemey, Camille Béchir, Nelly Gabanou, Mélissa Estermann, Fanny Bertrand‐Gaday, Christelle Pessemesse, Laurence Toupet, Karine Desprat, Romain Vialaret, Jérôme Hirtz, Christophe Noël, Danièle Jorgensen, Christian Casas, François Milhavet, Ollivier Lemaitre, Jean‐Marc Aging Cell Research Articles Recent advances in cell reprogramming showed that OSKM induction is able to improve cell physiology in vitro and in vivo. Here, we show that a single short reprogramming induction is sufficient to prevent musculoskeletal functions deterioration of mice, when applied in early life. In addition, in old age, treated mice have improved tissue structures in kidney, spleen, skin, and lung, with an increased lifespan of 15% associated with organ‐specific differential age‐related DNA methylation signatures rejuvenated by the treatment. Altogether, our results indicate that a single short reprogramming early in life might initiate and propagate an epigenetically related mechanism to promote a healthy lifespan. John Wiley and Sons Inc. 2022-10-17 2022-11 /pmc/articles/PMC9649606/ /pubmed/36251933 http://dx.doi.org/10.1111/acel.13714 Text en © 2022 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Research Articles Alle, Quentin Le Borgne, Enora Bensadoun, Paul Lemey, Camille Béchir, Nelly Gabanou, Mélissa Estermann, Fanny Bertrand‐Gaday, Christelle Pessemesse, Laurence Toupet, Karine Desprat, Romain Vialaret, Jérôme Hirtz, Christophe Noël, Danièle Jorgensen, Christian Casas, François Milhavet, Ollivier Lemaitre, Jean‐Marc A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan |
| title | A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan |
| title_full | A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan |
| title_fullStr | A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan |
| title_full_unstemmed | A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan |
| title_short | A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan |
| title_sort | single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan |
| topic | Research Articles |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649606/ https://www.ncbi.nlm.nih.gov/pubmed/36251933 http://dx.doi.org/10.1111/acel.13714 |
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