A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan

Recent advances in cell reprogramming showed that OSKM induction is able to improve cell physiology in vitro and in vivo. Here, we show that a single short reprogramming induction is sufficient to prevent musculoskeletal functions deterioration of mice, when applied in early life. In addition, in ol...

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Detalles Bibliográficos
Autores principales: Alle, Quentin, Le Borgne, Enora, Bensadoun, Paul, Lemey, Camille, Béchir, Nelly, Gabanou, Mélissa, Estermann, Fanny, Bertrand‐Gaday, Christelle, Pessemesse, Laurence, Toupet, Karine, Desprat, Romain, Vialaret, Jérôme, Hirtz, Christophe, Noël, Danièle, Jorgensen, Christian, Casas, François, Milhavet, Ollivier, Lemaitre, Jean‐Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649606/
https://www.ncbi.nlm.nih.gov/pubmed/36251933
http://dx.doi.org/10.1111/acel.13714

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