Inhibition of USP1 activates ER stress through Ubi-protein aggregation to induce autophagy and apoptosis in HCC

The deubiquitinating enzyme USP1 (ubiquitin-specific protease 1) plays a role in the progression of various tumors, emerging as a potential therapeutic target. This study aimed to determine the role of USP1 as a therapeutic target in hepatocellular carcinoma (HCC). We detected USP1 expression in the...

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Detalles Bibliográficos
Autores principales: Wang, Longhao, Hu, Tao, Shen, Zhibo, Zheng, Yuanyuan, Geng, Qishun, Li, Lifeng, Sha, Beibei, Li, Miaomiao, Sun, Yaxin, Guo, Yongjun, Xue, Wenhua, Xuan, Dan, Chen, Ping, Zhao, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649627/
https://www.ncbi.nlm.nih.gov/pubmed/36357365
http://dx.doi.org/10.1038/s41419-022-05341-3

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