R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations

LRRK2 mutations are closely associated with Parkinson’s disease (PD). Convergent evidence suggests that LRRK2 regulates striatal function. Here, by using knock-in mouse lines expressing the two most common LRRK2 pathogenic mutations—G2019S and R1441C—we investigated how LRRK2 mutations altered stria...

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Detalles Bibliográficos
Autores principales: Xenias, Harry S., Chen, Chuyu, Kang, Shuo, Cherian, Suraj, Situ, Xiaolei, Shanmugasundaram, Bharanidharan, Liu, Guoxiang, Scesa, Giuseppe, Savio Chan, C., Parisiadou, Loukia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649688/
https://www.ncbi.nlm.nih.gov/pubmed/36357506
http://dx.doi.org/10.1038/s42003-022-04136-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649688/
https://www.ncbi.nlm.nih.gov/pubmed/36357506
http://dx.doi.org/10.1038/s42003-022-04136-8

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