Novel protein complexes containing autophagy and UPS components regulate proteasome-dependent PARK2 recruitment onto mitochondria and PARK2-PARK6 activity during mitophagy

Autophagy is an evolutionarily conserved eukaryotic cellular mechanism through which cytosolic fragments, misfolded/aggregated proteins and organelles are degraded and recycled. Priming of mitochondria through ubiquitylation is required for the clearance the organelle by autophagy (mitophagy). Famil...

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Detalles Bibliográficos
Autores principales: Kocaturk, Nur Mehpare, Peker, Nesibe, Eberhart, Karin, Akkoc, Yunus, Deveci, Gamze, Dengjel, Joern, Gozuacik, Devrim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649694/
https://www.ncbi.nlm.nih.gov/pubmed/36357363
http://dx.doi.org/10.1038/s41419-022-05339-x

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