A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience

Cells adapt to cold by increasing levels of unsaturated phospholipids and membrane fluidity through conserved homeostatic mechanisms. Here we report an exceptionally large and evolutionarily conserved protein LPD-3 in C. elegans that mediates lipid trafficking to confer cold resilience. We identify...

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Detalles Bibliográficos
Autores principales: Wang, Changnan, Wang, Bingying, Pandey, Taruna, Long, Yong, Zhang, Jianxiu, Oh, Fiona, Sima, Jessica, Guo, Ruyin, Liu, Yun, Zhang, Chao, Mukherjee, Shaeri, Bassik, Michael, Lin, Weichun, Deng, Huichao, Vale, Goncalo, McDonald, Jeffrey G., Shen, Kang, Ma, Dengke K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649747/
https://www.ncbi.nlm.nih.gov/pubmed/36357390
http://dx.doi.org/10.1038/s41467-022-34450-y

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