MYBPC3 deficiency in cardiac fibroblasts drives their activation and contributes to fibrosis

Genetic mutations in the MYBPC3 gene encoding cardiac myosin binding protein C (cMyBP-C) are the most common cause of hypertrophic cardiomyopathy (HCM). Myocardial fibrosis (MF) plays a critical role in the development of HCM. However, the mechanism for mutant MYBPC3-induced MF is not well defined....

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Detalles Bibliográficos
Autores principales: Zou, Xiaodong, Ouyang, Hongsheng, Lin, Feng, Zhang, Huanyu, Yang, Yang, Pang, Daxin, Han, Renzhi, Tang, Xiaochun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649783/
https://www.ncbi.nlm.nih.gov/pubmed/36357371
http://dx.doi.org/10.1038/s41419-022-05403-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649783/
https://www.ncbi.nlm.nih.gov/pubmed/36357371
http://dx.doi.org/10.1038/s41419-022-05403-6

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