Cargando…

MYBPC3 deficiency in cardiac fibroblasts drives their activation and contributes to fibrosis

Genetic mutations in the MYBPC3 gene encoding cardiac myosin binding protein C (cMyBP-C) are the most common cause of hypertrophic cardiomyopathy (HCM). Myocardial fibrosis (MF) plays a critical role in the development of HCM. However, the mechanism for mutant MYBPC3-induced MF is not well defined....

Descripción completa

Detalles Bibliográficos
Autores principales:	Zou, Xiaodong, Ouyang, Hongsheng, Lin, Feng, Zhang, Huanyu, Yang, Yang, Pang, Daxin, Han, Renzhi, Tang, Xiaochun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649783/ https://www.ncbi.nlm.nih.gov/pubmed/36357371 http://dx.doi.org/10.1038/s41419-022-05403-6

Ejemplares similares

Pathological alterations in the gastrointestinal tract of a porcine model of DMD
por: Zou, Xiaodong, et al.
Publicado: (2021)

Clostridium butyricum and Bifidobacterium pseudolongum Attenuate the Development of Cardiac Fibrosis in Mice
por: Wang, Jiaqi, et al.
Publicado: (2022)

Cholesterol Biosynthesis Modulates CSFV Replication
por: Zou, Xiaodong, et al.
Publicado: (2022)

Lactate facilitates classical swine fever virus replication by enhancing cholesterol biosynthesis
por: Zou, Xiaodong, et al.
Publicado: (2022)

Preparation of a new type 2 diabetic miniature pig model via the CRISPR/Cas9 system
por: Zou, Xiaodong, et al.
Publicado: (2019)

Optimization of a CRISPR/Cas9-mediated Knock-in Strategy at the Porcine Rosa26 Locus in Porcine Foetal Fibroblasts
por: Xie, Zicong, et al.
Publicado: (2017)

Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload
por: Ma, Zhen, et al.
Publicado: (2018)

Efficient Generation of Orthologous Point Mutations in Pigs via CRISPR-assisted ssODN-mediated Homology-directed Repair
por: Wang, Kankan, et al.
Publicado: (2016)

Current Status of Genetically Modified Pigs That Are Resistant to Virus Infection
por: Yuan, Hongming, et al.
Publicado: (2022)

Generation of PCBP1-deficient pigs using CRISPR/Cas9-mediated gene editing
por: Qi, Chunyun, et al.
Publicado: (2022)

Is MYBPC3 linked to bicuspid aortic valve?
por: Niaz, Talha, et al.
Publicado: (2021)

CRISPR/Cas9-mediated knockin of human factor IX into swine factor IX locus effectively alleviates bleeding in hemophilia B pigs
por: Chen, Jiahuan, et al.
Publicado: (2020)

Novel MYBPC3 Mutations in Indian Population with Cardiomyopathies
por: Rani, Deepa Selvi, et al.
Publicado: (2023)

An Update on MYBPC3 Gene Mutation in Hypertrophic Cardiomyopathy
por: Tudurachi, Bogdan-Sorin, et al.
Publicado: (2023)

Cardiac Fibrosis and Fibroblasts
por: Kurose, Hitoshi
Publicado: (2021)

Autosomal Recessive Transmission of MYBPC3 Mutation Results in Malignant Phenotype of Hypertrophic Cardiomyopathy
por: Wang, Yilu, et al.
Publicado: (2013)

N-3 polyunsaturated fatty acids attenuates triglyceride and inflammatory factors level in hfat-1 transgenic pigs
por: Liu, Xingxing, et al.
Publicado: (2016)

Germ cell‐specific expression of Cre recombinase using the VASA promoter in the pig
por: Song, Yuning, et al.
Publicado: (2015)

Targeted Mybpc3 Knock-Out Mice with Cardiac Hypertrophy Exhibit Structural Mitral Valve Abnormalities
por: Judge, Daniel P., et al.
Publicado: (2015)

Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation
por: Lynch, Thomas L., et al.
Publicado: (2015)

MYBPC2 and MYL1 as Significant Gene Markers for Rhabdomyosarcoma
por: Chen, Zihang, et al.
Publicado: (2021)

MYBPC1 is a key regulator for laryngeal carcinoma formation
por: Liu, Jing, et al.
Publicado: (2022)

Is haploinsufficiency a sufficient mechanism for MYBPC3 truncating mutations?
por: Barefield, David Y.
Publicado: (2023)

Myocardial fibrosis comparison by cmr between genetically positive HCM patients with MYBPC3 and MYH7 gene mutations
por: Villanueva, Alejandra, et al.
Publicado: (2015)

Apolipoprotein CIII regulates lipoprotein-associated phospholipase A(2) expression via the MAPK and NFκB pathways
por: Han, Xiaolei, et al.
Publicado: (2015)

TERT Promoter Revertant Mutation Inhibits Melanoma Growth through Intrinsic Apoptosis
por: Wang, Yanbing, et al.
Publicado: (2022)

Correction: Wang et al. TERT Promoter Revertant Mutation Inhibits Melanoma Growth through Intrinsic Apoptosis. Biology 2022, 11, 141
por: Wang, Yanbing, et al.
Publicado: (2022)

Large-Scale CRISPR Screen of LDLR Pathogenic Variants
por: Li, Mengjing, et al.
Publicado: (2023)

Transcriptome Analysis of Cardiac Hypertrophic Growth in MYBPC3-Null Mice Suggests Early Responders in Hypertrophic Remodeling
por: Farrell, Emily, et al.
Publicado: (2018)

Evaluation of a polymorphism in MYBPC3 in patients with anthracycline induced cardiotoxicity
por: Vinodhini, M. Thirumalai, et al.
Publicado: (2018)

An interesting Mybpc3 heterozygous mutation associated with bicuspid aortic valve
por: Zhao, Xiaopei, et al.
Publicado: (2020)

Sarcomeric deficits underlie MYBPC1-associated myopathy with myogenic tremor
por: Geist Hauserman, Janelle, et al.
Publicado: (2021)

Identification and Functional Analysis of the Regulatory Elements in the pHSPA6 Promoter
por: Jiao, Shuyu, et al.
Publicado: (2022)

The Relationship between Changes in MYBPC3 Single-Nucleotide Polymorphism-Associated Metabolites and Elite Athletes’ Adaptive Cardiac Function
por: Riguene, Emna, et al.
Publicado: (2023)

Oxidatively stressed extracellular microenvironment drives fibroblast activation and kidney fibrosis
por: Li, Li, et al.
Publicado: (2023)

Immunogenicity evaluation of inactivated virus and purified proteins of porcine circovirus type 2 in mice
por: Liu, Xiaohui, et al.
Publicado: (2018)

Cardiac Fibroblasts and Cardiac Fibrosis: Precise Role of Exosomes
por: Ranjan, Prabhat, et al.
Publicado: (2019)

PEDV: Insights and Advances into Types, Function, Structure, and Receptor Recognition
por: Lin, Feng, et al.
Publicado: (2022)

Adverse events in families with hypertrophic or dilated cardiomyopathy and mutations in the MYBPC3 gene
por: Ehlermann, Philipp, et al.
Publicado: (2008)

Familial hypertrophic cardiomyopathy associated with a new mutation in gene MYBPC3
por: Aurensanz Clemente, Esther, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_cc4b0ianig976rlme8m1i94q1r