Maprotiline restores ER homeostasis and rescues neurodegeneration via Histamine Receptor H1 inhibition in retinal ganglion cells

When the protein or calcium homeostasis of the endoplasmic reticulum (ER) is adversely altered, cells experience ER stress that leads to various diseases including neurodegeneration. Genetic deletion of an ER stress downstream effector, CHOP, significantly protects neuron somata and axons. Here we r...

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Detalles Bibliográficos
Autores principales: Chen, Wei, Liu, Pingting, Liu, Dong, Huang, Haoliang, Feng, Xue, Fang, Fang, Li, Liang, Wu, Jian, Liu, Liang, Solow-Cordero, David E., Hu, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649812/
https://www.ncbi.nlm.nih.gov/pubmed/36357388
http://dx.doi.org/10.1038/s41467-022-34682-y

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